Cargando…
En bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: A case report
Malignant pleural mesothelioma (MPM) is associated with previous asbestos exposure, while more clinical insights into this disease have come from other case studies. Maximal cytoreduction is critical in disease control and might help to improve the prognosis. Here, a 41‐year‐old female presented wit...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599967/ https://www.ncbi.nlm.nih.gov/pubmed/37658846 http://dx.doi.org/10.1111/1759-7714.15095 |
_version_ | 1785125883184414720 |
---|---|
author | Qin, Changlong Xia, Qinghong Chen, Zi‐Jia Zhou, Qinghua Zheng, Xi |
author_facet | Qin, Changlong Xia, Qinghong Chen, Zi‐Jia Zhou, Qinghua Zheng, Xi |
author_sort | Qin, Changlong |
collection | PubMed |
description | Malignant pleural mesothelioma (MPM) is associated with previous asbestos exposure, while more clinical insights into this disease have come from other case studies. Maximal cytoreduction is critical in disease control and might help to improve the prognosis. Here, a 41‐year‐old female presented with a 6‐month history of a mass detected in the chest wall following resection of a right pleural mesothelioma 2 years previously. A fluorodeoxyglucose positron emission tomography/computed tomography scan showed a right chest wall mass with a blurred boundary 8.9 cm × 3.7 cm in size. The patient had received one cycle of bevacizumab, carboplatin, and pemetrexed, and two cycles of nivolumab, ipilimumab, and gemcitabine 5 months before admission. We subsequently resected the tumor, the involved diaphragm, and the fifth and sixth ribs, and titanium mesh and continuous suture were used to close the thoracic cage. The fixed paraffin‐embedded tissues showed epithelioid pleural mesothelioma. The patient received nivolumab and ipilimumab postoperatively, and no recurrence was detected 16 months after surgery. En bloc resection with reconstructive surgery effectively removed the locally advanced malignancy and restored the biological function of the thorax with a favorable prognosis. Neoadjuvant immunotherapy might therefore be conducive to radical resection and perioperative immunotherapy might improve the prognosis. |
format | Online Article Text |
id | pubmed-10599967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-105999672023-10-27 En bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: A case report Qin, Changlong Xia, Qinghong Chen, Zi‐Jia Zhou, Qinghua Zheng, Xi Thorac Cancer Case Report Malignant pleural mesothelioma (MPM) is associated with previous asbestos exposure, while more clinical insights into this disease have come from other case studies. Maximal cytoreduction is critical in disease control and might help to improve the prognosis. Here, a 41‐year‐old female presented with a 6‐month history of a mass detected in the chest wall following resection of a right pleural mesothelioma 2 years previously. A fluorodeoxyglucose positron emission tomography/computed tomography scan showed a right chest wall mass with a blurred boundary 8.9 cm × 3.7 cm in size. The patient had received one cycle of bevacizumab, carboplatin, and pemetrexed, and two cycles of nivolumab, ipilimumab, and gemcitabine 5 months before admission. We subsequently resected the tumor, the involved diaphragm, and the fifth and sixth ribs, and titanium mesh and continuous suture were used to close the thoracic cage. The fixed paraffin‐embedded tissues showed epithelioid pleural mesothelioma. The patient received nivolumab and ipilimumab postoperatively, and no recurrence was detected 16 months after surgery. En bloc resection with reconstructive surgery effectively removed the locally advanced malignancy and restored the biological function of the thorax with a favorable prognosis. Neoadjuvant immunotherapy might therefore be conducive to radical resection and perioperative immunotherapy might improve the prognosis. John Wiley & Sons Australia, Ltd 2023-09-02 /pmc/articles/PMC10599967/ /pubmed/37658846 http://dx.doi.org/10.1111/1759-7714.15095 Text en © 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Report Qin, Changlong Xia, Qinghong Chen, Zi‐Jia Zhou, Qinghua Zheng, Xi En bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: A case report |
title | En bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: A case report |
title_full | En bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: A case report |
title_fullStr | En bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: A case report |
title_full_unstemmed | En bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: A case report |
title_short | En bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: A case report |
title_sort | en bloc resection of the recurrent pleural mesothelioma and reconstruction of the chest wall after immunotherapy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599967/ https://www.ncbi.nlm.nih.gov/pubmed/37658846 http://dx.doi.org/10.1111/1759-7714.15095 |
work_keys_str_mv | AT qinchanglong enblocresectionoftherecurrentpleuralmesotheliomaandreconstructionofthechestwallafterimmunotherapyacasereport AT xiaqinghong enblocresectionoftherecurrentpleuralmesotheliomaandreconstructionofthechestwallafterimmunotherapyacasereport AT chenzijia enblocresectionoftherecurrentpleuralmesotheliomaandreconstructionofthechestwallafterimmunotherapyacasereport AT zhouqinghua enblocresectionoftherecurrentpleuralmesotheliomaandreconstructionofthechestwallafterimmunotherapyacasereport AT zhengxi enblocresectionoftherecurrentpleuralmesotheliomaandreconstructionofthechestwallafterimmunotherapyacasereport |