Ebf3(+) niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells

Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors. Here, we show that in mice whose CXC chemokine ligand 12 (CXCL12) is deleted from half HSC niche cells, termed CXC chemokin...

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Detalles Bibliográficos
Autores principales: Nakatani, Taichi, Sugiyama, Tatsuki, Omatsu, Yoshiki, Watanabe, Hitomi, Kondoh, Gen, Nagasawa, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600098/
https://www.ncbi.nlm.nih.gov/pubmed/37880234
http://dx.doi.org/10.1038/s41467-023-42047-2

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