Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth

Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 oncoproteins stimulate de novo serine/glycine synthesis and essential amino acids intake, promoting breast cancer growt...

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Detalles Bibliográficos
Autores principales: Tombari, Camilla, Zannini, Alessandro, Bertolio, Rebecca, Pedretti, Silvia, Audano, Matteo, Triboli, Luca, Cancila, Valeria, Vacca, Davide, Caputo, Manuel, Donzelli, Sara, Segatto, Ilenia, Vodret, Simone, Piazza, Silvano, Rustighi, Alessandra, Mantovani, Fiamma, Belletti, Barbara, Baldassarre, Gustavo, Blandino, Giovanni, Tripodo, Claudio, Bicciato, Silvio, Mitro, Nico, Del Sal, Giannino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600207/
https://www.ncbi.nlm.nih.gov/pubmed/37880212
http://dx.doi.org/10.1038/s41467-023-42458-1

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