MED19 encodes two unique protein isoforms that confer prostate cancer growth under low androgen through distinct gene expression programs

MED19, a component of the mediator complex and a co-regulator of the androgen receptor (AR), is pivotal in prostate cancer cell proliferation. MED19 has two isoforms: a full-length “canonical” and a shorter “alternative” variant. Specific antibodies were developed to investigate these isoforms. Both...

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Detalles Bibliográficos
Autores principales: Ruoff, Rachel, Weber, Hannah, Wang, Ying, Huang, Hongying, Shapiro, Ellen, Fenyö, David, Garabedian, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600210/
https://www.ncbi.nlm.nih.gov/pubmed/37880276
http://dx.doi.org/10.1038/s41598-023-45199-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600210/
https://www.ncbi.nlm.nih.gov/pubmed/37880276
http://dx.doi.org/10.1038/s41598-023-45199-9

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