Effective clearance of rituximab-resistant tumor cells by breaking the mirror-symmetry of immunoglobulin G and simultaneous binding to CD55 and CD20

Complement-dependent cytotoxicity (CDC), which eliminates aberrant target cells through the assembly and complex formation of serum complement molecules, is one of the major effector functions of anticancer therapeutic antibodies. In this study, we discovered that breaking the symmetry of natural im...

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Detalles Bibliográficos
Autores principales: Lee, Sang Min, Min, Sung-Won, Kwon, Hyeong Sun, Bae, Gong-Deuk, Jung, Ji Hae, Park, Hye In, Lee, Seung Hyeon, Lim, Chung Su, Ko, Byoung Joon, Lee, Ji Chul, Jung, Sang Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600224/
https://www.ncbi.nlm.nih.gov/pubmed/37880350
http://dx.doi.org/10.1038/s41598-023-45491-8

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