Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor prognosis. TOP2A is a key enzyme in DNA replication and is a therapeutic target for breast and other cancers. TOP2A-specific Th1-promoting epitopes with optimal binding affinity to MHC II were identified u...

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Detalles Bibliográficos
Autores principales: Lee, Sang Beom, Pan, Jing, Xiong, Donghai, Palen, Katie, Johnson, Bryon, Lubet, Ronald A., Shoemaker, Robert H., Green, Jeffrey E., Fernando, Romaine Ingrid, Sei, Shizuko, You, Ming, Wang, Yian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600249/
https://www.ncbi.nlm.nih.gov/pubmed/37880313
http://dx.doi.org/10.1038/s41698-023-00461-1

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