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Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer
PURPOSE: As the number of long-term survivors of pancreatic cancer is expected to increase thanks to recent advances in multidisciplinary treatment and earlier diagnoses of pancreatic cancer, we are likely to encounter more cases of postoperative pulmonary nodules. We analyzed the clinical course an...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600288/ https://www.ncbi.nlm.nih.gov/pubmed/37314516 http://dx.doi.org/10.1007/s00595-023-02701-0 |
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author | Miyashita, Yudai Ose, Naoko Okami, Jiro Takami, Koji Sakamaki, Yasushi Ikeda, Naoki Hayakawa, Masanobu Higashiyama, Masahiko Kodama, Ken Susaki, Yoshiyuki Funakoshi, Yasunobu Maeda, Jun Shintani, Yasushi |
author_facet | Miyashita, Yudai Ose, Naoko Okami, Jiro Takami, Koji Sakamaki, Yasushi Ikeda, Naoki Hayakawa, Masanobu Higashiyama, Masahiko Kodama, Ken Susaki, Yoshiyuki Funakoshi, Yasunobu Maeda, Jun Shintani, Yasushi |
author_sort | Miyashita, Yudai |
collection | PubMed |
description | PURPOSE: As the number of long-term survivors of pancreatic cancer is expected to increase thanks to recent advances in multidisciplinary treatment and earlier diagnoses of pancreatic cancer, we are likely to encounter more cases of postoperative pulmonary nodules. We analyzed the clinical course and prognosis of resection of pulmonary metastases from pancreatic cancer to clarify the prognostic implication of pulmonary metastasectomy for pancreatic cancer. METHOD: We retrospectively analyzed 35 patients who underwent resection of lung metastases after pancreatic cancer surgery. Short- and long-term outcomes and factors associated with the prognosis were analyzed. RESULTS: The observation period was 20 (range, 1–101) months, with 3- and 5-year survival rates of 88.3% and 64.5% from pancreatectomy and 44.1% and 28.3% from lung resection, respectively. A univariate analysis revealed that a period from pancreatic cancer resection to pulmonary nodule shadow detection of < 15 months was associated with a significantly lower overall survival from pancreatic resection than a longer period. Conversely, histological type, stage, size of lung metastases, and resection technique were not associated with the overall survival. CONCLUSION: A long-term prognosis may be expected in some cases with a disease-free interval of ≥ 15 months. Our findings suggest that the disease-free interval may influence the prognosis. |
format | Online Article Text |
id | pubmed-10600288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-106002882023-10-27 Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer Miyashita, Yudai Ose, Naoko Okami, Jiro Takami, Koji Sakamaki, Yasushi Ikeda, Naoki Hayakawa, Masanobu Higashiyama, Masahiko Kodama, Ken Susaki, Yoshiyuki Funakoshi, Yasunobu Maeda, Jun Shintani, Yasushi Surg Today Original Article PURPOSE: As the number of long-term survivors of pancreatic cancer is expected to increase thanks to recent advances in multidisciplinary treatment and earlier diagnoses of pancreatic cancer, we are likely to encounter more cases of postoperative pulmonary nodules. We analyzed the clinical course and prognosis of resection of pulmonary metastases from pancreatic cancer to clarify the prognostic implication of pulmonary metastasectomy for pancreatic cancer. METHOD: We retrospectively analyzed 35 patients who underwent resection of lung metastases after pancreatic cancer surgery. Short- and long-term outcomes and factors associated with the prognosis were analyzed. RESULTS: The observation period was 20 (range, 1–101) months, with 3- and 5-year survival rates of 88.3% and 64.5% from pancreatectomy and 44.1% and 28.3% from lung resection, respectively. A univariate analysis revealed that a period from pancreatic cancer resection to pulmonary nodule shadow detection of < 15 months was associated with a significantly lower overall survival from pancreatic resection than a longer period. Conversely, histological type, stage, size of lung metastases, and resection technique were not associated with the overall survival. CONCLUSION: A long-term prognosis may be expected in some cases with a disease-free interval of ≥ 15 months. Our findings suggest that the disease-free interval may influence the prognosis. Springer Nature Singapore 2023-06-14 2023 /pmc/articles/PMC10600288/ /pubmed/37314516 http://dx.doi.org/10.1007/s00595-023-02701-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Miyashita, Yudai Ose, Naoko Okami, Jiro Takami, Koji Sakamaki, Yasushi Ikeda, Naoki Hayakawa, Masanobu Higashiyama, Masahiko Kodama, Ken Susaki, Yoshiyuki Funakoshi, Yasunobu Maeda, Jun Shintani, Yasushi Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer |
title | Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer |
title_full | Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer |
title_fullStr | Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer |
title_full_unstemmed | Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer |
title_short | Outcomes of surgical resection for pulmonary metastasis from pancreatic cancer |
title_sort | outcomes of surgical resection for pulmonary metastasis from pancreatic cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600288/ https://www.ncbi.nlm.nih.gov/pubmed/37314516 http://dx.doi.org/10.1007/s00595-023-02701-0 |
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