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Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motor...

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Autores principales: Lu, Dengfeng, Feng, Yun, Liu, Guangjie, Yang, Yayi, Ren, Yubo, Chen, Zhouqing, Sun, Xiaoou, Guan, Yixiang, Wang, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600463/
https://www.ncbi.nlm.nih.gov/pubmed/37901436
http://dx.doi.org/10.3389/fnins.2023.1268883
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author Lu, Dengfeng
Feng, Yun
Liu, Guangjie
Yang, Yayi
Ren, Yubo
Chen, Zhouqing
Sun, Xiaoou
Guan, Yixiang
Wang, Zhong
author_facet Lu, Dengfeng
Feng, Yun
Liu, Guangjie
Yang, Yayi
Ren, Yubo
Chen, Zhouqing
Sun, Xiaoou
Guan, Yixiang
Wang, Zhong
author_sort Lu, Dengfeng
collection PubMed
description Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motors and adaptors associated with the anterograde and retrograde transport of mitochondria. Subsequently, we review the modest evidence involving mitochondrial transport mechanisms that has surfaced in acute neurological disorders, including traumatic brain injury, spinal cord injury, spontaneous intracerebral hemorrhage, and ischemic stroke. An in-depth study of this area will help deepen our understanding of the mechanisms underlying the development of various acute neurological disorders and ultimately improve therapeutic options.
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spelling pubmed-106004632023-10-27 Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders Lu, Dengfeng Feng, Yun Liu, Guangjie Yang, Yayi Ren, Yubo Chen, Zhouqing Sun, Xiaoou Guan, Yixiang Wang, Zhong Front Neurosci Neuroscience Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motors and adaptors associated with the anterograde and retrograde transport of mitochondria. Subsequently, we review the modest evidence involving mitochondrial transport mechanisms that has surfaced in acute neurological disorders, including traumatic brain injury, spinal cord injury, spontaneous intracerebral hemorrhage, and ischemic stroke. An in-depth study of this area will help deepen our understanding of the mechanisms underlying the development of various acute neurological disorders and ultimately improve therapeutic options. Frontiers Media S.A. 2023-10-12 /pmc/articles/PMC10600463/ /pubmed/37901436 http://dx.doi.org/10.3389/fnins.2023.1268883 Text en Copyright © 2023 Lu, Feng, Liu, Yang, Ren, Chen, Sun, Guan and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lu, Dengfeng
Feng, Yun
Liu, Guangjie
Yang, Yayi
Ren, Yubo
Chen, Zhouqing
Sun, Xiaoou
Guan, Yixiang
Wang, Zhong
Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders
title Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders
title_full Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders
title_fullStr Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders
title_full_unstemmed Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders
title_short Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders
title_sort mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600463/
https://www.ncbi.nlm.nih.gov/pubmed/37901436
http://dx.doi.org/10.3389/fnins.2023.1268883
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