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Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders
Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motor...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600463/ https://www.ncbi.nlm.nih.gov/pubmed/37901436 http://dx.doi.org/10.3389/fnins.2023.1268883 |
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author | Lu, Dengfeng Feng, Yun Liu, Guangjie Yang, Yayi Ren, Yubo Chen, Zhouqing Sun, Xiaoou Guan, Yixiang Wang, Zhong |
author_facet | Lu, Dengfeng Feng, Yun Liu, Guangjie Yang, Yayi Ren, Yubo Chen, Zhouqing Sun, Xiaoou Guan, Yixiang Wang, Zhong |
author_sort | Lu, Dengfeng |
collection | PubMed |
description | Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motors and adaptors associated with the anterograde and retrograde transport of mitochondria. Subsequently, we review the modest evidence involving mitochondrial transport mechanisms that has surfaced in acute neurological disorders, including traumatic brain injury, spinal cord injury, spontaneous intracerebral hemorrhage, and ischemic stroke. An in-depth study of this area will help deepen our understanding of the mechanisms underlying the development of various acute neurological disorders and ultimately improve therapeutic options. |
format | Online Article Text |
id | pubmed-10600463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106004632023-10-27 Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders Lu, Dengfeng Feng, Yun Liu, Guangjie Yang, Yayi Ren, Yubo Chen, Zhouqing Sun, Xiaoou Guan, Yixiang Wang, Zhong Front Neurosci Neuroscience Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motors and adaptors associated with the anterograde and retrograde transport of mitochondria. Subsequently, we review the modest evidence involving mitochondrial transport mechanisms that has surfaced in acute neurological disorders, including traumatic brain injury, spinal cord injury, spontaneous intracerebral hemorrhage, and ischemic stroke. An in-depth study of this area will help deepen our understanding of the mechanisms underlying the development of various acute neurological disorders and ultimately improve therapeutic options. Frontiers Media S.A. 2023-10-12 /pmc/articles/PMC10600463/ /pubmed/37901436 http://dx.doi.org/10.3389/fnins.2023.1268883 Text en Copyright © 2023 Lu, Feng, Liu, Yang, Ren, Chen, Sun, Guan and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Lu, Dengfeng Feng, Yun Liu, Guangjie Yang, Yayi Ren, Yubo Chen, Zhouqing Sun, Xiaoou Guan, Yixiang Wang, Zhong Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders |
title | Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders |
title_full | Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders |
title_fullStr | Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders |
title_full_unstemmed | Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders |
title_short | Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders |
title_sort | mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600463/ https://www.ncbi.nlm.nih.gov/pubmed/37901436 http://dx.doi.org/10.3389/fnins.2023.1268883 |
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