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Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus

BACKGROUND: Dysregulation of feeding behavior leads to a variety of pathological manifestations ranging from obesity to anorexia. The foraging behavior of animals affected by food deficiency is not fully understood. METHODS: Home-Cage system was used to monitor the behaviors. Immunohistochemical sta...

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Autores principales: Wu, Shanshan, Wang, Jing, Xu, Yang, Zhang, Zicheng, Jin, Xinchen, Liang, Yixiao, Ge, Yueping, Zhan, Huidong, Peng, Li, Luo, Dandan, Li, Mengzhu, Bi, Wenkai, Guan, Qingbo, He, Zhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600490/
https://www.ncbi.nlm.nih.gov/pubmed/37899828
http://dx.doi.org/10.3389/fnut.2023.1278906
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author Wu, Shanshan
Wang, Jing
Xu, Yang
Zhang, Zicheng
Jin, Xinchen
Liang, Yixiao
Ge, Yueping
Zhan, Huidong
Peng, Li
Luo, Dandan
Li, Mengzhu
Bi, Wenkai
Guan, Qingbo
He, Zhao
author_facet Wu, Shanshan
Wang, Jing
Xu, Yang
Zhang, Zicheng
Jin, Xinchen
Liang, Yixiao
Ge, Yueping
Zhan, Huidong
Peng, Li
Luo, Dandan
Li, Mengzhu
Bi, Wenkai
Guan, Qingbo
He, Zhao
author_sort Wu, Shanshan
collection PubMed
description BACKGROUND: Dysregulation of feeding behavior leads to a variety of pathological manifestations ranging from obesity to anorexia. The foraging behavior of animals affected by food deficiency is not fully understood. METHODS: Home-Cage system was used to monitor the behaviors. Immunohistochemical staining was used to monitor the trend of neuronal activity. Chemogenetic approach was used to modify neuronal activity. RESULTS: We described here a unique mouse model of foraging behavior and unveiled that food deprivation significantly increases the general activities of mice with a daily rhythmic pattern, particularly foraging behavior. The increased foraging behavior is potentiated by food cues (mouthfeel, odor, size, and shape) and energy deficit, rather than macronutrient protein, carbohydrate, and fat. Notably, energy deficiency increases nocturnal neuronal activity in paraventricular hypothalamic nucleus (PVH), accompanying a similar change in rhythmic foraging behavior. Activating neuronal activity in PVH enhances the amplitude of foraging behavior in mice. Conversely, inactivating neuronal activity in PVH decreases the amplitude of foraging behavior and impairs the rhythm of foraging behavior. DISCUSSION: These results illustrate that energy status and food cues regulate the rhythmic foraging behavior via PVH neuronal activity. Understanding foraging behavior provides insights into the underlying mechanism of eating-related disorders.
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spelling pubmed-106004902023-10-27 Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus Wu, Shanshan Wang, Jing Xu, Yang Zhang, Zicheng Jin, Xinchen Liang, Yixiao Ge, Yueping Zhan, Huidong Peng, Li Luo, Dandan Li, Mengzhu Bi, Wenkai Guan, Qingbo He, Zhao Front Nutr Nutrition BACKGROUND: Dysregulation of feeding behavior leads to a variety of pathological manifestations ranging from obesity to anorexia. The foraging behavior of animals affected by food deficiency is not fully understood. METHODS: Home-Cage system was used to monitor the behaviors. Immunohistochemical staining was used to monitor the trend of neuronal activity. Chemogenetic approach was used to modify neuronal activity. RESULTS: We described here a unique mouse model of foraging behavior and unveiled that food deprivation significantly increases the general activities of mice with a daily rhythmic pattern, particularly foraging behavior. The increased foraging behavior is potentiated by food cues (mouthfeel, odor, size, and shape) and energy deficit, rather than macronutrient protein, carbohydrate, and fat. Notably, energy deficiency increases nocturnal neuronal activity in paraventricular hypothalamic nucleus (PVH), accompanying a similar change in rhythmic foraging behavior. Activating neuronal activity in PVH enhances the amplitude of foraging behavior in mice. Conversely, inactivating neuronal activity in PVH decreases the amplitude of foraging behavior and impairs the rhythm of foraging behavior. DISCUSSION: These results illustrate that energy status and food cues regulate the rhythmic foraging behavior via PVH neuronal activity. Understanding foraging behavior provides insights into the underlying mechanism of eating-related disorders. Frontiers Media S.A. 2023-10-12 /pmc/articles/PMC10600490/ /pubmed/37899828 http://dx.doi.org/10.3389/fnut.2023.1278906 Text en Copyright © 2023 Wu, Wang, Xu, Zhang, Jin, Liang, Ge, Zhan, Peng, Luo, Li, Bi, Guan and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Wu, Shanshan
Wang, Jing
Xu, Yang
Zhang, Zicheng
Jin, Xinchen
Liang, Yixiao
Ge, Yueping
Zhan, Huidong
Peng, Li
Luo, Dandan
Li, Mengzhu
Bi, Wenkai
Guan, Qingbo
He, Zhao
Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus
title Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus
title_full Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus
title_fullStr Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus
title_full_unstemmed Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus
title_short Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus
title_sort energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600490/
https://www.ncbi.nlm.nih.gov/pubmed/37899828
http://dx.doi.org/10.3389/fnut.2023.1278906
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