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Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus
BACKGROUND: Dysregulation of feeding behavior leads to a variety of pathological manifestations ranging from obesity to anorexia. The foraging behavior of animals affected by food deficiency is not fully understood. METHODS: Home-Cage system was used to monitor the behaviors. Immunohistochemical sta...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600490/ https://www.ncbi.nlm.nih.gov/pubmed/37899828 http://dx.doi.org/10.3389/fnut.2023.1278906 |
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author | Wu, Shanshan Wang, Jing Xu, Yang Zhang, Zicheng Jin, Xinchen Liang, Yixiao Ge, Yueping Zhan, Huidong Peng, Li Luo, Dandan Li, Mengzhu Bi, Wenkai Guan, Qingbo He, Zhao |
author_facet | Wu, Shanshan Wang, Jing Xu, Yang Zhang, Zicheng Jin, Xinchen Liang, Yixiao Ge, Yueping Zhan, Huidong Peng, Li Luo, Dandan Li, Mengzhu Bi, Wenkai Guan, Qingbo He, Zhao |
author_sort | Wu, Shanshan |
collection | PubMed |
description | BACKGROUND: Dysregulation of feeding behavior leads to a variety of pathological manifestations ranging from obesity to anorexia. The foraging behavior of animals affected by food deficiency is not fully understood. METHODS: Home-Cage system was used to monitor the behaviors. Immunohistochemical staining was used to monitor the trend of neuronal activity. Chemogenetic approach was used to modify neuronal activity. RESULTS: We described here a unique mouse model of foraging behavior and unveiled that food deprivation significantly increases the general activities of mice with a daily rhythmic pattern, particularly foraging behavior. The increased foraging behavior is potentiated by food cues (mouthfeel, odor, size, and shape) and energy deficit, rather than macronutrient protein, carbohydrate, and fat. Notably, energy deficiency increases nocturnal neuronal activity in paraventricular hypothalamic nucleus (PVH), accompanying a similar change in rhythmic foraging behavior. Activating neuronal activity in PVH enhances the amplitude of foraging behavior in mice. Conversely, inactivating neuronal activity in PVH decreases the amplitude of foraging behavior and impairs the rhythm of foraging behavior. DISCUSSION: These results illustrate that energy status and food cues regulate the rhythmic foraging behavior via PVH neuronal activity. Understanding foraging behavior provides insights into the underlying mechanism of eating-related disorders. |
format | Online Article Text |
id | pubmed-10600490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106004902023-10-27 Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus Wu, Shanshan Wang, Jing Xu, Yang Zhang, Zicheng Jin, Xinchen Liang, Yixiao Ge, Yueping Zhan, Huidong Peng, Li Luo, Dandan Li, Mengzhu Bi, Wenkai Guan, Qingbo He, Zhao Front Nutr Nutrition BACKGROUND: Dysregulation of feeding behavior leads to a variety of pathological manifestations ranging from obesity to anorexia. The foraging behavior of animals affected by food deficiency is not fully understood. METHODS: Home-Cage system was used to monitor the behaviors. Immunohistochemical staining was used to monitor the trend of neuronal activity. Chemogenetic approach was used to modify neuronal activity. RESULTS: We described here a unique mouse model of foraging behavior and unveiled that food deprivation significantly increases the general activities of mice with a daily rhythmic pattern, particularly foraging behavior. The increased foraging behavior is potentiated by food cues (mouthfeel, odor, size, and shape) and energy deficit, rather than macronutrient protein, carbohydrate, and fat. Notably, energy deficiency increases nocturnal neuronal activity in paraventricular hypothalamic nucleus (PVH), accompanying a similar change in rhythmic foraging behavior. Activating neuronal activity in PVH enhances the amplitude of foraging behavior in mice. Conversely, inactivating neuronal activity in PVH decreases the amplitude of foraging behavior and impairs the rhythm of foraging behavior. DISCUSSION: These results illustrate that energy status and food cues regulate the rhythmic foraging behavior via PVH neuronal activity. Understanding foraging behavior provides insights into the underlying mechanism of eating-related disorders. Frontiers Media S.A. 2023-10-12 /pmc/articles/PMC10600490/ /pubmed/37899828 http://dx.doi.org/10.3389/fnut.2023.1278906 Text en Copyright © 2023 Wu, Wang, Xu, Zhang, Jin, Liang, Ge, Zhan, Peng, Luo, Li, Bi, Guan and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Wu, Shanshan Wang, Jing Xu, Yang Zhang, Zicheng Jin, Xinchen Liang, Yixiao Ge, Yueping Zhan, Huidong Peng, Li Luo, Dandan Li, Mengzhu Bi, Wenkai Guan, Qingbo He, Zhao Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus |
title | Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus |
title_full | Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus |
title_fullStr | Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus |
title_full_unstemmed | Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus |
title_short | Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus |
title_sort | energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600490/ https://www.ncbi.nlm.nih.gov/pubmed/37899828 http://dx.doi.org/10.3389/fnut.2023.1278906 |
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