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Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits

The aim of this study was to measure the concentrations of enrofloxacin (ERFX) and other fluoroquinolones; orbifloxacin (OBFX), marbofloxacin (MBFX), and ofloxacin (OFLX) in the plasma and bile of rabbits after a single intravenous (IV) injection. Twenty male rabbits were divided into four groups an...

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Autores principales: SHIMADA, Sumire, ABOUBAKR, Mohamed, ELBADAWY, Mohamed, USUI, Tatsuya, SASAKI, Kazuaki, SHIMODA, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600534/
https://www.ncbi.nlm.nih.gov/pubmed/37635088
http://dx.doi.org/10.1292/jvms.23-0246
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author SHIMADA, Sumire
ABOUBAKR, Mohamed
ELBADAWY, Mohamed
USUI, Tatsuya
SASAKI, Kazuaki
SHIMODA, Minoru
author_facet SHIMADA, Sumire
ABOUBAKR, Mohamed
ELBADAWY, Mohamed
USUI, Tatsuya
SASAKI, Kazuaki
SHIMODA, Minoru
author_sort SHIMADA, Sumire
collection PubMed
description The aim of this study was to measure the concentrations of enrofloxacin (ERFX) and other fluoroquinolones; orbifloxacin (OBFX), marbofloxacin (MBFX), and ofloxacin (OFLX) in the plasma and bile of rabbits after a single intravenous (IV) injection. Twenty male rabbits were divided into four groups and given each drug by IV injection into the ear vein at a dose of 5.0 mg/kg BW. The concentration of ERFX, ciprofloxacin (CPFX), OBFX, MBFX and OFLX in plasma and bile were determined by HPLC. CPFX, metabolite of ERFX, was also measured by HPLC in plasma and bile of rabbits receiving ERFX. Several pharmacokinetic parameters in plasma were calculated and biliary clearance (CL(bile)) was calculated from extent of biliary excretion and accumulation of AUC of each drug. After IV injection, elimination half-life (t(1/2β)) was 4.13, 3.68, 6.60, 5.14 hr; volume of distribution at a steady state (V(dss)) was 1.24, 0.503, 0.771, 1.02 L/kg; and total body clearance (CL(tot)) was 1.05, 0.418, 0.271, 0.453 L/kg/hr, respectively. The values for CL(bile) for ERFX, OBFX, MBFX, and OFLX were 0.0048, 0.0050, 0.0057, and 0.0094 L/kg/hr, respectively. These values represent 0.48%, 1.2%, 2.1%, and 2.3% of the total body clearance (CL(tot)) of each drug, respectively. The biliary clearance of CPFX was also measured and found to be 0.0199 L/kg/hr with ERFX administration. The results showed that ERFX, OBFX, MBFX, and OFLX were not excreted into the bile to a significant extent, making them safe drugs to use in rabbits.
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spelling pubmed-106005342023-10-27 Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits SHIMADA, Sumire ABOUBAKR, Mohamed ELBADAWY, Mohamed USUI, Tatsuya SASAKI, Kazuaki SHIMODA, Minoru J Vet Med Sci Pharmacology The aim of this study was to measure the concentrations of enrofloxacin (ERFX) and other fluoroquinolones; orbifloxacin (OBFX), marbofloxacin (MBFX), and ofloxacin (OFLX) in the plasma and bile of rabbits after a single intravenous (IV) injection. Twenty male rabbits were divided into four groups and given each drug by IV injection into the ear vein at a dose of 5.0 mg/kg BW. The concentration of ERFX, ciprofloxacin (CPFX), OBFX, MBFX and OFLX in plasma and bile were determined by HPLC. CPFX, metabolite of ERFX, was also measured by HPLC in plasma and bile of rabbits receiving ERFX. Several pharmacokinetic parameters in plasma were calculated and biliary clearance (CL(bile)) was calculated from extent of biliary excretion and accumulation of AUC of each drug. After IV injection, elimination half-life (t(1/2β)) was 4.13, 3.68, 6.60, 5.14 hr; volume of distribution at a steady state (V(dss)) was 1.24, 0.503, 0.771, 1.02 L/kg; and total body clearance (CL(tot)) was 1.05, 0.418, 0.271, 0.453 L/kg/hr, respectively. The values for CL(bile) for ERFX, OBFX, MBFX, and OFLX were 0.0048, 0.0050, 0.0057, and 0.0094 L/kg/hr, respectively. These values represent 0.48%, 1.2%, 2.1%, and 2.3% of the total body clearance (CL(tot)) of each drug, respectively. The biliary clearance of CPFX was also measured and found to be 0.0199 L/kg/hr with ERFX administration. The results showed that ERFX, OBFX, MBFX, and OFLX were not excreted into the bile to a significant extent, making them safe drugs to use in rabbits. The Japanese Society of Veterinary Science 2023-08-25 2023-10 /pmc/articles/PMC10600534/ /pubmed/37635088 http://dx.doi.org/10.1292/jvms.23-0246 Text en ©2023 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pharmacology
SHIMADA, Sumire
ABOUBAKR, Mohamed
ELBADAWY, Mohamed
USUI, Tatsuya
SASAKI, Kazuaki
SHIMODA, Minoru
Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits
title Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits
title_full Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits
title_fullStr Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits
title_full_unstemmed Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits
title_short Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits
title_sort biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600534/
https://www.ncbi.nlm.nih.gov/pubmed/37635088
http://dx.doi.org/10.1292/jvms.23-0246
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