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Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits
The aim of this study was to measure the concentrations of enrofloxacin (ERFX) and other fluoroquinolones; orbifloxacin (OBFX), marbofloxacin (MBFX), and ofloxacin (OFLX) in the plasma and bile of rabbits after a single intravenous (IV) injection. Twenty male rabbits were divided into four groups an...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society of Veterinary Science
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600534/ https://www.ncbi.nlm.nih.gov/pubmed/37635088 http://dx.doi.org/10.1292/jvms.23-0246 |
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author | SHIMADA, Sumire ABOUBAKR, Mohamed ELBADAWY, Mohamed USUI, Tatsuya SASAKI, Kazuaki SHIMODA, Minoru |
author_facet | SHIMADA, Sumire ABOUBAKR, Mohamed ELBADAWY, Mohamed USUI, Tatsuya SASAKI, Kazuaki SHIMODA, Minoru |
author_sort | SHIMADA, Sumire |
collection | PubMed |
description | The aim of this study was to measure the concentrations of enrofloxacin (ERFX) and other fluoroquinolones; orbifloxacin (OBFX), marbofloxacin (MBFX), and ofloxacin (OFLX) in the plasma and bile of rabbits after a single intravenous (IV) injection. Twenty male rabbits were divided into four groups and given each drug by IV injection into the ear vein at a dose of 5.0 mg/kg BW. The concentration of ERFX, ciprofloxacin (CPFX), OBFX, MBFX and OFLX in plasma and bile were determined by HPLC. CPFX, metabolite of ERFX, was also measured by HPLC in plasma and bile of rabbits receiving ERFX. Several pharmacokinetic parameters in plasma were calculated and biliary clearance (CL(bile)) was calculated from extent of biliary excretion and accumulation of AUC of each drug. After IV injection, elimination half-life (t(1/2β)) was 4.13, 3.68, 6.60, 5.14 hr; volume of distribution at a steady state (V(dss)) was 1.24, 0.503, 0.771, 1.02 L/kg; and total body clearance (CL(tot)) was 1.05, 0.418, 0.271, 0.453 L/kg/hr, respectively. The values for CL(bile) for ERFX, OBFX, MBFX, and OFLX were 0.0048, 0.0050, 0.0057, and 0.0094 L/kg/hr, respectively. These values represent 0.48%, 1.2%, 2.1%, and 2.3% of the total body clearance (CL(tot)) of each drug, respectively. The biliary clearance of CPFX was also measured and found to be 0.0199 L/kg/hr with ERFX administration. The results showed that ERFX, OBFX, MBFX, and OFLX were not excreted into the bile to a significant extent, making them safe drugs to use in rabbits. |
format | Online Article Text |
id | pubmed-10600534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-106005342023-10-27 Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits SHIMADA, Sumire ABOUBAKR, Mohamed ELBADAWY, Mohamed USUI, Tatsuya SASAKI, Kazuaki SHIMODA, Minoru J Vet Med Sci Pharmacology The aim of this study was to measure the concentrations of enrofloxacin (ERFX) and other fluoroquinolones; orbifloxacin (OBFX), marbofloxacin (MBFX), and ofloxacin (OFLX) in the plasma and bile of rabbits after a single intravenous (IV) injection. Twenty male rabbits were divided into four groups and given each drug by IV injection into the ear vein at a dose of 5.0 mg/kg BW. The concentration of ERFX, ciprofloxacin (CPFX), OBFX, MBFX and OFLX in plasma and bile were determined by HPLC. CPFX, metabolite of ERFX, was also measured by HPLC in plasma and bile of rabbits receiving ERFX. Several pharmacokinetic parameters in plasma were calculated and biliary clearance (CL(bile)) was calculated from extent of biliary excretion and accumulation of AUC of each drug. After IV injection, elimination half-life (t(1/2β)) was 4.13, 3.68, 6.60, 5.14 hr; volume of distribution at a steady state (V(dss)) was 1.24, 0.503, 0.771, 1.02 L/kg; and total body clearance (CL(tot)) was 1.05, 0.418, 0.271, 0.453 L/kg/hr, respectively. The values for CL(bile) for ERFX, OBFX, MBFX, and OFLX were 0.0048, 0.0050, 0.0057, and 0.0094 L/kg/hr, respectively. These values represent 0.48%, 1.2%, 2.1%, and 2.3% of the total body clearance (CL(tot)) of each drug, respectively. The biliary clearance of CPFX was also measured and found to be 0.0199 L/kg/hr with ERFX administration. The results showed that ERFX, OBFX, MBFX, and OFLX were not excreted into the bile to a significant extent, making them safe drugs to use in rabbits. The Japanese Society of Veterinary Science 2023-08-25 2023-10 /pmc/articles/PMC10600534/ /pubmed/37635088 http://dx.doi.org/10.1292/jvms.23-0246 Text en ©2023 The Japanese Society of Veterinary Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Pharmacology SHIMADA, Sumire ABOUBAKR, Mohamed ELBADAWY, Mohamed USUI, Tatsuya SASAKI, Kazuaki SHIMODA, Minoru Biliary excretion and pharmacokinetics of several fluoroquinolones after intravenous injection in rabbits |
title | Biliary excretion and pharmacokinetics of several fluoroquinolones after
intravenous injection in rabbits |
title_full | Biliary excretion and pharmacokinetics of several fluoroquinolones after
intravenous injection in rabbits |
title_fullStr | Biliary excretion and pharmacokinetics of several fluoroquinolones after
intravenous injection in rabbits |
title_full_unstemmed | Biliary excretion and pharmacokinetics of several fluoroquinolones after
intravenous injection in rabbits |
title_short | Biliary excretion and pharmacokinetics of several fluoroquinolones after
intravenous injection in rabbits |
title_sort | biliary excretion and pharmacokinetics of several fluoroquinolones after
intravenous injection in rabbits |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600534/ https://www.ncbi.nlm.nih.gov/pubmed/37635088 http://dx.doi.org/10.1292/jvms.23-0246 |
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