Podoplanin promotes cell proliferation, survival, and migration of canine non-tonsillar squamous cell carcinoma

Podoplanin (PDPN) is a prognostic factor and is involved in several mechanisms of tumor progression in human squamous cell carcinoma (SCC). Canine non-tonsillar SCC (NTSCC) is a common oral tumor in dogs and has a highly invasive characteristic. In this study, we investigated the function of PDPN in...

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Detalles Bibliográficos
Autores principales: SHINADA, Masahiro, KATO, Daiki, TSUBOI, Masaya, IKEDA, Namiko, AOKI, Susumu, IGUCHI, Takaaki, LI, Toshio, KODERA, Yuka, OTA, Ryosuke, KOSEKI, Shoma, SHIBAHARA, Hayato, TAKAHASHI, Yosuke, HASHIMOTO, Yuko, CHAMBERS, James K, UCHIDA, Kazuyuki, NOGUCHI, Shunsuke, KATO, Yukinari, NISHIMURA, Ryohei, NAKAGAWA, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2023
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600541/
https://www.ncbi.nlm.nih.gov/pubmed/37544715
http://dx.doi.org/10.1292/jvms.23-0062
Descripción
Sumario:Podoplanin (PDPN) is a prognostic factor and is involved in several mechanisms of tumor progression in human squamous cell carcinoma (SCC). Canine non-tonsillar SCC (NTSCC) is a common oral tumor in dogs and has a highly invasive characteristic. In this study, we investigated the function of PDPN in canine NTSCC. In canine NTSCC clinical samples, PDPN overexpression was observed in 80% of dogs with NTSCC, and PDPN expression was related to ki67 expression. In PDPN knocked-out canine NTSCC cells, cell proliferation, cancer stemness, and migration were suppressed. As the mechanism of PDPN-mediated cell proliferation, PDPN knocked-out induced apoptosis and G2/M cell cycle arrest in canine NTSCC cells. These findings suggest that PDPN promotes tumor malignancies and may be a novel biomarker and therapeutic target for canine NTSCC.

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