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Naples Prognostic Score and Clinical Outcomes in Pulmonary Arterial Hypertension Patients
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a specific form of pulmonary hypertension characterized by an increased mean pulmonary arterial pressure. Risk stratification is crucial in managing PAH, using various clinical, laboratory, and imaging parameters. The Naples prognostic score (NPS)...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Med Bull Sisli Etfal Hosp
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600604/ https://www.ncbi.nlm.nih.gov/pubmed/37900336 http://dx.doi.org/10.14744/SEMB.2023.82783 |
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author | Arugaslan, Emre Kalayci, Suleyman Tufekcioglu, Omac |
author_facet | Arugaslan, Emre Kalayci, Suleyman Tufekcioglu, Omac |
author_sort | Arugaslan, Emre |
collection | PubMed |
description | OBJECTIVES: Pulmonary arterial hypertension (PAH) is a specific form of pulmonary hypertension characterized by an increased mean pulmonary arterial pressure. Risk stratification is crucial in managing PAH, using various clinical, laboratory, and imaging parameters. The Naples prognostic score (NPS), incorporating nutritional and inflammatory markers, has demonstrated prognostic value in other conditions but not in PAH. The goal of this study was to appraise the importance of NPS as a prognostic indicator for patients with PAH. METHODS: This retrospective study involved 101 PAH patients. Echocardiographic, laboratory, and right heart catheterization data were collected. Statistical analyses compared variables between survivors and non-survivors, and multivariate logistic regression identified mortality risk factors. RESULTS: Among the 101 patients, 18 died within the follow-up period. The mortality group showed elevated levels of B-type natriuretic peptide (BNP) and significantly higher median NPS. Patients were categorized based on their NPS scores, revealing higher mortality in Group 2. Multivariate logistic regression identified age and BNP levels as independent predictors of mortality. The inclusion of NPS in the model further reinforced its association with mortality. CONCLUSION: The study suggests that NPS is linked to poor outcomes in PAH patients. NPS, a straightforward and easily calculated score, holds the potential to predict the clinical trajectory of PAH, offering advantages for risk assessment in this population. |
format | Online Article Text |
id | pubmed-10600604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Med Bull Sisli Etfal Hosp |
record_format | MEDLINE/PubMed |
spelling | pubmed-106006042023-10-27 Naples Prognostic Score and Clinical Outcomes in Pulmonary Arterial Hypertension Patients Arugaslan, Emre Kalayci, Suleyman Tufekcioglu, Omac Sisli Etfal Hastan Tip Bul Original Research OBJECTIVES: Pulmonary arterial hypertension (PAH) is a specific form of pulmonary hypertension characterized by an increased mean pulmonary arterial pressure. Risk stratification is crucial in managing PAH, using various clinical, laboratory, and imaging parameters. The Naples prognostic score (NPS), incorporating nutritional and inflammatory markers, has demonstrated prognostic value in other conditions but not in PAH. The goal of this study was to appraise the importance of NPS as a prognostic indicator for patients with PAH. METHODS: This retrospective study involved 101 PAH patients. Echocardiographic, laboratory, and right heart catheterization data were collected. Statistical analyses compared variables between survivors and non-survivors, and multivariate logistic regression identified mortality risk factors. RESULTS: Among the 101 patients, 18 died within the follow-up period. The mortality group showed elevated levels of B-type natriuretic peptide (BNP) and significantly higher median NPS. Patients were categorized based on their NPS scores, revealing higher mortality in Group 2. Multivariate logistic regression identified age and BNP levels as independent predictors of mortality. The inclusion of NPS in the model further reinforced its association with mortality. CONCLUSION: The study suggests that NPS is linked to poor outcomes in PAH patients. NPS, a straightforward and easily calculated score, holds the potential to predict the clinical trajectory of PAH, offering advantages for risk assessment in this population. Med Bull Sisli Etfal Hosp 2023-09-29 /pmc/articles/PMC10600604/ /pubmed/37900336 http://dx.doi.org/10.14744/SEMB.2023.82783 Text en ©Copyright 2023 by The Medical Bulletin of Sisli Etfal Hospital https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Original Research Arugaslan, Emre Kalayci, Suleyman Tufekcioglu, Omac Naples Prognostic Score and Clinical Outcomes in Pulmonary Arterial Hypertension Patients |
title | Naples Prognostic Score and Clinical Outcomes in Pulmonary Arterial Hypertension Patients |
title_full | Naples Prognostic Score and Clinical Outcomes in Pulmonary Arterial Hypertension Patients |
title_fullStr | Naples Prognostic Score and Clinical Outcomes in Pulmonary Arterial Hypertension Patients |
title_full_unstemmed | Naples Prognostic Score and Clinical Outcomes in Pulmonary Arterial Hypertension Patients |
title_short | Naples Prognostic Score and Clinical Outcomes in Pulmonary Arterial Hypertension Patients |
title_sort | naples prognostic score and clinical outcomes in pulmonary arterial hypertension patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600604/ https://www.ncbi.nlm.nih.gov/pubmed/37900336 http://dx.doi.org/10.14744/SEMB.2023.82783 |
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