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Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke

OBJECTIVES: This study aimed to investigate the clinical data of patients with acute ischemic stroke who received low-dose intravenous (IV) thrombolytic therapy (0.9 mg/kg; maximum 50 mg) for various reasons, compare the obtained results with those of patients who received standard-dose thrombolytic...

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Autores principales: Cetiner, Mustafa, Eskut, Neslihan, Akdag, Gonul, Arikan, Fatma Akkoyun, Guler, Merve, Kabay, Sibel Canbaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Med Bull Sisli Etfal Hosp 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600607/
https://www.ncbi.nlm.nih.gov/pubmed/37900337
http://dx.doi.org/10.14744/SEMB.2023.51437
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author Cetiner, Mustafa
Eskut, Neslihan
Akdag, Gonul
Arikan, Fatma Akkoyun
Guler, Merve
Kabay, Sibel Canbaz
author_facet Cetiner, Mustafa
Eskut, Neslihan
Akdag, Gonul
Arikan, Fatma Akkoyun
Guler, Merve
Kabay, Sibel Canbaz
author_sort Cetiner, Mustafa
collection PubMed
description OBJECTIVES: This study aimed to investigate the clinical data of patients with acute ischemic stroke who received low-dose intravenous (IV) thrombolytic therapy (0.9 mg/kg; maximum 50 mg) for various reasons, compare the obtained results with those of patients who received standard-dose thrombolytic therapy, and discuss them in light of the literature. METHODS: Patients who received IV thrombolytic therapy within 4.5 h of symptom onset between January 2015 and June 2018 were retrospectively reviewed. Patients were divided into the low-dose group (0.9 mg/kg; max. 50 mg) and the standard-dose group (0.9 mg/kg; max 90 mg) according to the thrombolytic therapy dose, after which demographic data and clinical results were analyzed. RESULTS: A total of 109 patients receiving thrombolytic therapy (19 patients in the low-dose group and 90 patients in the standard-dose group) were included in the study. There was no significant difference between the two groups in terms of good outcome rates (47.4% vs. 52.2%). There was no statistically significant difference in terms of symptomatic and asymptomatic intracerebral hemorrhage rates. CONCLUSION: Our study showed similar efficacy and safety for low-dose IV thrombolytic therapy compared with standard-dose IV thrombolytic therapy administered within 4.5 h of symptom onset in patients with acute ischemic stroke.
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spelling pubmed-106006072023-10-27 Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Cetiner, Mustafa Eskut, Neslihan Akdag, Gonul Arikan, Fatma Akkoyun Guler, Merve Kabay, Sibel Canbaz Sisli Etfal Hastan Tip Bul Original Research OBJECTIVES: This study aimed to investigate the clinical data of patients with acute ischemic stroke who received low-dose intravenous (IV) thrombolytic therapy (0.9 mg/kg; maximum 50 mg) for various reasons, compare the obtained results with those of patients who received standard-dose thrombolytic therapy, and discuss them in light of the literature. METHODS: Patients who received IV thrombolytic therapy within 4.5 h of symptom onset between January 2015 and June 2018 were retrospectively reviewed. Patients were divided into the low-dose group (0.9 mg/kg; max. 50 mg) and the standard-dose group (0.9 mg/kg; max 90 mg) according to the thrombolytic therapy dose, after which demographic data and clinical results were analyzed. RESULTS: A total of 109 patients receiving thrombolytic therapy (19 patients in the low-dose group and 90 patients in the standard-dose group) were included in the study. There was no significant difference between the two groups in terms of good outcome rates (47.4% vs. 52.2%). There was no statistically significant difference in terms of symptomatic and asymptomatic intracerebral hemorrhage rates. CONCLUSION: Our study showed similar efficacy and safety for low-dose IV thrombolytic therapy compared with standard-dose IV thrombolytic therapy administered within 4.5 h of symptom onset in patients with acute ischemic stroke. Med Bull Sisli Etfal Hosp 2023-09-29 /pmc/articles/PMC10600607/ /pubmed/37900337 http://dx.doi.org/10.14744/SEMB.2023.51437 Text en ©Copyright 2023 by The Medical Bulletin of Sisli Etfal Hospital https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Original Research
Cetiner, Mustafa
Eskut, Neslihan
Akdag, Gonul
Arikan, Fatma Akkoyun
Guler, Merve
Kabay, Sibel Canbaz
Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke
title Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke
title_full Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke
title_fullStr Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke
title_full_unstemmed Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke
title_short Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke
title_sort retrospective evaluation of the results of low-dose intravenous thrombolytic therapy in acute ischemic stroke
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600607/
https://www.ncbi.nlm.nih.gov/pubmed/37900337
http://dx.doi.org/10.14744/SEMB.2023.51437
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