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Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke
OBJECTIVES: This study aimed to investigate the clinical data of patients with acute ischemic stroke who received low-dose intravenous (IV) thrombolytic therapy (0.9 mg/kg; maximum 50 mg) for various reasons, compare the obtained results with those of patients who received standard-dose thrombolytic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Med Bull Sisli Etfal Hosp
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600607/ https://www.ncbi.nlm.nih.gov/pubmed/37900337 http://dx.doi.org/10.14744/SEMB.2023.51437 |
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author | Cetiner, Mustafa Eskut, Neslihan Akdag, Gonul Arikan, Fatma Akkoyun Guler, Merve Kabay, Sibel Canbaz |
author_facet | Cetiner, Mustafa Eskut, Neslihan Akdag, Gonul Arikan, Fatma Akkoyun Guler, Merve Kabay, Sibel Canbaz |
author_sort | Cetiner, Mustafa |
collection | PubMed |
description | OBJECTIVES: This study aimed to investigate the clinical data of patients with acute ischemic stroke who received low-dose intravenous (IV) thrombolytic therapy (0.9 mg/kg; maximum 50 mg) for various reasons, compare the obtained results with those of patients who received standard-dose thrombolytic therapy, and discuss them in light of the literature. METHODS: Patients who received IV thrombolytic therapy within 4.5 h of symptom onset between January 2015 and June 2018 were retrospectively reviewed. Patients were divided into the low-dose group (0.9 mg/kg; max. 50 mg) and the standard-dose group (0.9 mg/kg; max 90 mg) according to the thrombolytic therapy dose, after which demographic data and clinical results were analyzed. RESULTS: A total of 109 patients receiving thrombolytic therapy (19 patients in the low-dose group and 90 patients in the standard-dose group) were included in the study. There was no significant difference between the two groups in terms of good outcome rates (47.4% vs. 52.2%). There was no statistically significant difference in terms of symptomatic and asymptomatic intracerebral hemorrhage rates. CONCLUSION: Our study showed similar efficacy and safety for low-dose IV thrombolytic therapy compared with standard-dose IV thrombolytic therapy administered within 4.5 h of symptom onset in patients with acute ischemic stroke. |
format | Online Article Text |
id | pubmed-10600607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Med Bull Sisli Etfal Hosp |
record_format | MEDLINE/PubMed |
spelling | pubmed-106006072023-10-27 Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Cetiner, Mustafa Eskut, Neslihan Akdag, Gonul Arikan, Fatma Akkoyun Guler, Merve Kabay, Sibel Canbaz Sisli Etfal Hastan Tip Bul Original Research OBJECTIVES: This study aimed to investigate the clinical data of patients with acute ischemic stroke who received low-dose intravenous (IV) thrombolytic therapy (0.9 mg/kg; maximum 50 mg) for various reasons, compare the obtained results with those of patients who received standard-dose thrombolytic therapy, and discuss them in light of the literature. METHODS: Patients who received IV thrombolytic therapy within 4.5 h of symptom onset between January 2015 and June 2018 were retrospectively reviewed. Patients were divided into the low-dose group (0.9 mg/kg; max. 50 mg) and the standard-dose group (0.9 mg/kg; max 90 mg) according to the thrombolytic therapy dose, after which demographic data and clinical results were analyzed. RESULTS: A total of 109 patients receiving thrombolytic therapy (19 patients in the low-dose group and 90 patients in the standard-dose group) were included in the study. There was no significant difference between the two groups in terms of good outcome rates (47.4% vs. 52.2%). There was no statistically significant difference in terms of symptomatic and asymptomatic intracerebral hemorrhage rates. CONCLUSION: Our study showed similar efficacy and safety for low-dose IV thrombolytic therapy compared with standard-dose IV thrombolytic therapy administered within 4.5 h of symptom onset in patients with acute ischemic stroke. Med Bull Sisli Etfal Hosp 2023-09-29 /pmc/articles/PMC10600607/ /pubmed/37900337 http://dx.doi.org/10.14744/SEMB.2023.51437 Text en ©Copyright 2023 by The Medical Bulletin of Sisli Etfal Hospital https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Original Research Cetiner, Mustafa Eskut, Neslihan Akdag, Gonul Arikan, Fatma Akkoyun Guler, Merve Kabay, Sibel Canbaz Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke |
title | Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke |
title_full | Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke |
title_fullStr | Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke |
title_full_unstemmed | Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke |
title_short | Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke |
title_sort | retrospective evaluation of the results of low-dose intravenous thrombolytic therapy in acute ischemic stroke |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600607/ https://www.ncbi.nlm.nih.gov/pubmed/37900337 http://dx.doi.org/10.14744/SEMB.2023.51437 |
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