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Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice
Acute kidney injury (AKI) is a serious pathophysiological event consequent to rhabdomyolysis. Inflammatory mechanisms play a role in the development of rhabdomyolysis-induced AKI. Citronellol (CT) is a naturally occurring monoterpene in essential oils of aromatic plant species. In this study, we exp...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600660/ https://www.ncbi.nlm.nih.gov/pubmed/37900084 http://dx.doi.org/10.25122/jml-2023-0102 |
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author | Mahmood, Yasameen Shakir Kathem, Sarmed Hashim |
author_facet | Mahmood, Yasameen Shakir Kathem, Sarmed Hashim |
author_sort | Mahmood, Yasameen Shakir |
collection | PubMed |
description | Acute kidney injury (AKI) is a serious pathophysiological event consequent to rhabdomyolysis. Inflammatory mechanisms play a role in the development of rhabdomyolysis-induced AKI. Citronellol (CT) is a naturally occurring monoterpene in essential oils of aromatic plant species. In this study, we explored the protective effects of citronellol on AKI resulting from glycerol-induced rhabdomyolysis. Rhabdomyolysis was induced by a single intramuscular injection of glycerol 50% (10mg/kg) in the thigh caudal muscle. Four groups of mice were assigned, including a control group, a group administered with glycerol to induce AKI as a model, a group treated with glycerol plus 50mg/kg CT, and a group treated with glycerol plus 100mg/kg CT. The renal function of mice from all groups was evaluated using kidney histopathological changes and kidney injury molecule-1 (KIM-1). Myoglobin levels were measured to detect rhabdomyolysis. Apoptosis was evaluated by renal cleaved caspase-3 and BAX levels. Both doses of citronellol (50mg/kg and 100mg/kg) significantly reduced KIM-1 mRNA expression and myoglobin levels compared to the glycerol group. In addition, citronellol resulted in lower cleaved caspase-3 and BAX in the renal tissue, indicating that citronellol exerted an anti-apoptotic effect in AKI. Citronellol showed a reno-protective effect against rhabdomyolysis-induced AKI, which may be attributed to its anti-apoptotic effects. |
format | Online Article Text |
id | pubmed-10600660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106006602023-10-27 Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice Mahmood, Yasameen Shakir Kathem, Sarmed Hashim J Med Life Original Article Acute kidney injury (AKI) is a serious pathophysiological event consequent to rhabdomyolysis. Inflammatory mechanisms play a role in the development of rhabdomyolysis-induced AKI. Citronellol (CT) is a naturally occurring monoterpene in essential oils of aromatic plant species. In this study, we explored the protective effects of citronellol on AKI resulting from glycerol-induced rhabdomyolysis. Rhabdomyolysis was induced by a single intramuscular injection of glycerol 50% (10mg/kg) in the thigh caudal muscle. Four groups of mice were assigned, including a control group, a group administered with glycerol to induce AKI as a model, a group treated with glycerol plus 50mg/kg CT, and a group treated with glycerol plus 100mg/kg CT. The renal function of mice from all groups was evaluated using kidney histopathological changes and kidney injury molecule-1 (KIM-1). Myoglobin levels were measured to detect rhabdomyolysis. Apoptosis was evaluated by renal cleaved caspase-3 and BAX levels. Both doses of citronellol (50mg/kg and 100mg/kg) significantly reduced KIM-1 mRNA expression and myoglobin levels compared to the glycerol group. In addition, citronellol resulted in lower cleaved caspase-3 and BAX in the renal tissue, indicating that citronellol exerted an anti-apoptotic effect in AKI. Citronellol showed a reno-protective effect against rhabdomyolysis-induced AKI, which may be attributed to its anti-apoptotic effects. Carol Davila University Press 2023-07 /pmc/articles/PMC10600660/ /pubmed/37900084 http://dx.doi.org/10.25122/jml-2023-0102 Text en ©2023 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Mahmood, Yasameen Shakir Kathem, Sarmed Hashim Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice |
title | Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice |
title_full | Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice |
title_fullStr | Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice |
title_full_unstemmed | Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice |
title_short | Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice |
title_sort | protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600660/ https://www.ncbi.nlm.nih.gov/pubmed/37900084 http://dx.doi.org/10.25122/jml-2023-0102 |
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