Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study
Haemolytic uraemic syndrome (HUS) caused by infection with Shiga toxin-producing Escherichia coli (STEC) is a relatively rare but potentially fatal multisystem syndrome clinically characterised by acute kidney injury. This study aimed to provide robust estimates of paediatric HUS incidence in Englan...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cambridge University Press
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600734/ https://www.ncbi.nlm.nih.gov/pubmed/37655611 http://dx.doi.org/10.1017/S0950268823001413 |
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author | Byrne, Lisa Douglas, Amy Launders, Naomi Godbole, Gauri Lynn, Richard Inward, Carol Jenkins, Claire |
author_facet | Byrne, Lisa Douglas, Amy Launders, Naomi Godbole, Gauri Lynn, Richard Inward, Carol Jenkins, Claire |
author_sort | Byrne, Lisa |
collection | PubMed |
description | Haemolytic uraemic syndrome (HUS) caused by infection with Shiga toxin-producing Escherichia coli (STEC) is a relatively rare but potentially fatal multisystem syndrome clinically characterised by acute kidney injury. This study aimed to provide robust estimates of paediatric HUS incidence in England, Wales, Northern Ireland, and the Republic of Ireland by using data linkage and case reconciliation with existing surveillance systems, and to describe the characteristics of the condition. Between 2011 and 2014, 288 HUS patients were included in the study, of which 256 (89.5%) were diagnosed as typical HUS. The crude incidence of paediatric typical HUS was 0.78 per 100,000 person-years, although this varied by country, age, gender, and ethnicity. The majority of typical HUS cases were 1 to 4 years old (53.7%) and female (54.0%). Clinical symptoms included diarrhoea (96.5%) and/or bloody diarrhoea (71.9%), abdominal pain (68.4%), and fever (41.4%). Where STEC was isolated (59.3%), 92.8% of strains were STEC O157 and 7.2% were STEC O26. Comparison of the HUS case ascertainment to existing STEC surveillance data indicated an additional 166 HUS cases were captured during this study, highlighting the limitations of the current surveillance system for STEC for monitoring the clinical burden of STEC and capturing HUS cases. |
format | Online Article Text |
id | pubmed-10600734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106007342023-10-27 Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study Byrne, Lisa Douglas, Amy Launders, Naomi Godbole, Gauri Lynn, Richard Inward, Carol Jenkins, Claire Epidemiol Infect Original Paper Haemolytic uraemic syndrome (HUS) caused by infection with Shiga toxin-producing Escherichia coli (STEC) is a relatively rare but potentially fatal multisystem syndrome clinically characterised by acute kidney injury. This study aimed to provide robust estimates of paediatric HUS incidence in England, Wales, Northern Ireland, and the Republic of Ireland by using data linkage and case reconciliation with existing surveillance systems, and to describe the characteristics of the condition. Between 2011 and 2014, 288 HUS patients were included in the study, of which 256 (89.5%) were diagnosed as typical HUS. The crude incidence of paediatric typical HUS was 0.78 per 100,000 person-years, although this varied by country, age, gender, and ethnicity. The majority of typical HUS cases were 1 to 4 years old (53.7%) and female (54.0%). Clinical symptoms included diarrhoea (96.5%) and/or bloody diarrhoea (71.9%), abdominal pain (68.4%), and fever (41.4%). Where STEC was isolated (59.3%), 92.8% of strains were STEC O157 and 7.2% were STEC O26. Comparison of the HUS case ascertainment to existing STEC surveillance data indicated an additional 166 HUS cases were captured during this study, highlighting the limitations of the current surveillance system for STEC for monitoring the clinical burden of STEC and capturing HUS cases. Cambridge University Press 2023-09-01 /pmc/articles/PMC10600734/ /pubmed/37655611 http://dx.doi.org/10.1017/S0950268823001413 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and/or adaptation of the article. |
spellingShingle | Original Paper Byrne, Lisa Douglas, Amy Launders, Naomi Godbole, Gauri Lynn, Richard Inward, Carol Jenkins, Claire Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study |
title | Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study |
title_full | Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study |
title_fullStr | Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study |
title_full_unstemmed | Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study |
title_short | Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study |
title_sort | haemolytic uraemic syndrome in children england, wales, northern ireland, and ireland: a prospective cohort study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600734/ https://www.ncbi.nlm.nih.gov/pubmed/37655611 http://dx.doi.org/10.1017/S0950268823001413 |
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