Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study

Haemolytic uraemic syndrome (HUS) caused by infection with Shiga toxin-producing Escherichia coli (STEC) is a relatively rare but potentially fatal multisystem syndrome clinically characterised by acute kidney injury. This study aimed to provide robust estimates of paediatric HUS incidence in Englan...

Descripción completa

Detalles Bibliográficos
Autores principales: Byrne, Lisa, Douglas, Amy, Launders, Naomi, Godbole, Gauri, Lynn, Richard, Inward, Carol, Jenkins, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600734/
https://www.ncbi.nlm.nih.gov/pubmed/37655611
http://dx.doi.org/10.1017/S0950268823001413
_version_ 1785126049112129536
author Byrne, Lisa
Douglas, Amy
Launders, Naomi
Godbole, Gauri
Lynn, Richard
Inward, Carol
Jenkins, Claire
author_facet Byrne, Lisa
Douglas, Amy
Launders, Naomi
Godbole, Gauri
Lynn, Richard
Inward, Carol
Jenkins, Claire
author_sort Byrne, Lisa
collection PubMed
description Haemolytic uraemic syndrome (HUS) caused by infection with Shiga toxin-producing Escherichia coli (STEC) is a relatively rare but potentially fatal multisystem syndrome clinically characterised by acute kidney injury. This study aimed to provide robust estimates of paediatric HUS incidence in England, Wales, Northern Ireland, and the Republic of Ireland by using data linkage and case reconciliation with existing surveillance systems, and to describe the characteristics of the condition. Between 2011 and 2014, 288 HUS patients were included in the study, of which 256 (89.5%) were diagnosed as typical HUS. The crude incidence of paediatric typical HUS was 0.78 per 100,000 person-years, although this varied by country, age, gender, and ethnicity. The majority of typical HUS cases were 1 to 4 years old (53.7%) and female (54.0%). Clinical symptoms included diarrhoea (96.5%) and/or bloody diarrhoea (71.9%), abdominal pain (68.4%), and fever (41.4%). Where STEC was isolated (59.3%), 92.8% of strains were STEC O157 and 7.2% were STEC O26. Comparison of the HUS case ascertainment to existing STEC surveillance data indicated an additional 166 HUS cases were captured during this study, highlighting the limitations of the current surveillance system for STEC for monitoring the clinical burden of STEC and capturing HUS cases.
format Online
Article
Text
id pubmed-10600734
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cambridge University Press
record_format MEDLINE/PubMed
spelling pubmed-106007342023-10-27 Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study Byrne, Lisa Douglas, Amy Launders, Naomi Godbole, Gauri Lynn, Richard Inward, Carol Jenkins, Claire Epidemiol Infect Original Paper Haemolytic uraemic syndrome (HUS) caused by infection with Shiga toxin-producing Escherichia coli (STEC) is a relatively rare but potentially fatal multisystem syndrome clinically characterised by acute kidney injury. This study aimed to provide robust estimates of paediatric HUS incidence in England, Wales, Northern Ireland, and the Republic of Ireland by using data linkage and case reconciliation with existing surveillance systems, and to describe the characteristics of the condition. Between 2011 and 2014, 288 HUS patients were included in the study, of which 256 (89.5%) were diagnosed as typical HUS. The crude incidence of paediatric typical HUS was 0.78 per 100,000 person-years, although this varied by country, age, gender, and ethnicity. The majority of typical HUS cases were 1 to 4 years old (53.7%) and female (54.0%). Clinical symptoms included diarrhoea (96.5%) and/or bloody diarrhoea (71.9%), abdominal pain (68.4%), and fever (41.4%). Where STEC was isolated (59.3%), 92.8% of strains were STEC O157 and 7.2% were STEC O26. Comparison of the HUS case ascertainment to existing STEC surveillance data indicated an additional 166 HUS cases were captured during this study, highlighting the limitations of the current surveillance system for STEC for monitoring the clinical burden of STEC and capturing HUS cases. Cambridge University Press 2023-09-01 /pmc/articles/PMC10600734/ /pubmed/37655611 http://dx.doi.org/10.1017/S0950268823001413 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and/or adaptation of the article.
spellingShingle Original Paper
Byrne, Lisa
Douglas, Amy
Launders, Naomi
Godbole, Gauri
Lynn, Richard
Inward, Carol
Jenkins, Claire
Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study
title Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study
title_full Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study
title_fullStr Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study
title_full_unstemmed Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study
title_short Haemolytic uraemic syndrome in children England, Wales, Northern Ireland, and Ireland: A prospective cohort study
title_sort haemolytic uraemic syndrome in children england, wales, northern ireland, and ireland: a prospective cohort study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600734/
https://www.ncbi.nlm.nih.gov/pubmed/37655611
http://dx.doi.org/10.1017/S0950268823001413
work_keys_str_mv AT byrnelisa haemolyticuraemicsyndromeinchildrenenglandwalesnorthernirelandandirelandaprospectivecohortstudy
AT douglasamy haemolyticuraemicsyndromeinchildrenenglandwalesnorthernirelandandirelandaprospectivecohortstudy
AT laundersnaomi haemolyticuraemicsyndromeinchildrenenglandwalesnorthernirelandandirelandaprospectivecohortstudy
AT godbolegauri haemolyticuraemicsyndromeinchildrenenglandwalesnorthernirelandandirelandaprospectivecohortstudy
AT lynnrichard haemolyticuraemicsyndromeinchildrenenglandwalesnorthernirelandandirelandaprospectivecohortstudy
AT inwardcarol haemolyticuraemicsyndromeinchildrenenglandwalesnorthernirelandandirelandaprospectivecohortstudy
AT jenkinsclaire haemolyticuraemicsyndromeinchildrenenglandwalesnorthernirelandandirelandaprospectivecohortstudy