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Candida endocarditis: Update on management considerations

The rise in incidence rates of invasive candidiasis warrants an increase in attention and efforts toward preventing and treating this virulent infection. Cardiac involvement is one of the most feared sequelae and has a poor prognosis. Despite the introduction of several novel antifungal agents over...

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Autores principales: Jamil, Yasser, Akinleye, Akintayo, Mirzaei, Mojtaba, Lempel, Matthew, Farhat, Kassem, Pan, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600790/
https://www.ncbi.nlm.nih.gov/pubmed/37900901
http://dx.doi.org/10.4330/wjc.v15.i10.469
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author Jamil, Yasser
Akinleye, Akintayo
Mirzaei, Mojtaba
Lempel, Matthew
Farhat, Kassem
Pan, Samuel
author_facet Jamil, Yasser
Akinleye, Akintayo
Mirzaei, Mojtaba
Lempel, Matthew
Farhat, Kassem
Pan, Samuel
author_sort Jamil, Yasser
collection PubMed
description The rise in incidence rates of invasive candidiasis warrants an increase in attention and efforts toward preventing and treating this virulent infection. Cardiac involvement is one of the most feared sequelae and has a poor prognosis. Despite the introduction of several novel antifungal agents over the past quarter century, complications and mortality rates due to Candida endocarditis have remained high. Although fungal endocarditis has a mechanism similar to bacterial endocarditis, no specific diagnostic criteria or algorithm exists to help guide its management. Furthermore, recent data has questioned the current guidelines recommending a combined approach of antifungal agents with surgical valve or indwelling prostheses removal. With the emergence of multidrug-resistant Candida auris, a focus on improved prophylactic measures and management strategies is necessary.
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spelling pubmed-106007902023-10-27 Candida endocarditis: Update on management considerations Jamil, Yasser Akinleye, Akintayo Mirzaei, Mojtaba Lempel, Matthew Farhat, Kassem Pan, Samuel World J Cardiol Minireviews The rise in incidence rates of invasive candidiasis warrants an increase in attention and efforts toward preventing and treating this virulent infection. Cardiac involvement is one of the most feared sequelae and has a poor prognosis. Despite the introduction of several novel antifungal agents over the past quarter century, complications and mortality rates due to Candida endocarditis have remained high. Although fungal endocarditis has a mechanism similar to bacterial endocarditis, no specific diagnostic criteria or algorithm exists to help guide its management. Furthermore, recent data has questioned the current guidelines recommending a combined approach of antifungal agents with surgical valve or indwelling prostheses removal. With the emergence of multidrug-resistant Candida auris, a focus on improved prophylactic measures and management strategies is necessary. Baishideng Publishing Group Inc 2023-10-26 2023-10-26 /pmc/articles/PMC10600790/ /pubmed/37900901 http://dx.doi.org/10.4330/wjc.v15.i10.469 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Jamil, Yasser
Akinleye, Akintayo
Mirzaei, Mojtaba
Lempel, Matthew
Farhat, Kassem
Pan, Samuel
Candida endocarditis: Update on management considerations
title Candida endocarditis: Update on management considerations
title_full Candida endocarditis: Update on management considerations
title_fullStr Candida endocarditis: Update on management considerations
title_full_unstemmed Candida endocarditis: Update on management considerations
title_short Candida endocarditis: Update on management considerations
title_sort candida endocarditis: update on management considerations
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600790/
https://www.ncbi.nlm.nih.gov/pubmed/37900901
http://dx.doi.org/10.4330/wjc.v15.i10.469
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