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Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis
BACKGROUND: Noninvasive methods have been developed to detect fibrosis in many liver diseases due to the limits of liver biopsy. However, previous studies have focused primarily on chronic viral hepatitis and nonalcoholic fatty liver disease. The diagnostic value of transient elastography for autoim...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600811/ https://www.ncbi.nlm.nih.gov/pubmed/37900994 http://dx.doi.org/10.3748/wjg.v29.i39.5503 |
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author | Chen, Hong Shen, Yue Wu, Sheng-Di Zhu, Qin Weng, Cheng-Zhao Zhang, Jun Wang, Mei-Xia Jiang, Wei |
author_facet | Chen, Hong Shen, Yue Wu, Sheng-Di Zhu, Qin Weng, Cheng-Zhao Zhang, Jun Wang, Mei-Xia Jiang, Wei |
author_sort | Chen, Hong |
collection | PubMed |
description | BACKGROUND: Noninvasive methods have been developed to detect fibrosis in many liver diseases due to the limits of liver biopsy. However, previous studies have focused primarily on chronic viral hepatitis and nonalcoholic fatty liver disease. The diagnostic value of transient elastography for autoimmune liver diseases (AILDs) is worth studying. AIM: To compare the diagnostic accuracy of imaging techniques with serum biomarkers of fibrosis in AILD. METHODS: The PubMed, Cochrane Library and EMBASE databases were searched. Studies evaluating the efficacy of noninvasive methods in the diagnosis of AILDs [autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC)] were included. The summary area under the receiver operating characteristic curve (AUROC), diagnostic odds ratio, sensitivity and specificity were used to assess the accuracy of these noninvasive methods for staging fibrosis. RESULTS: A total of 60 articles were included in this study, and the number of patients with AIH, PBC and PSC was 1594, 3126 and 501, respectively. The summary AUROC of transient elastography in the diagnosis of significant fibrosis, advanced fibrosis and cirrhosis in patients with AIH were 0.84, 0.88 and 0.90, respectively, while those in patients with PBC were 0.93, 0.93 and 0.91, respectively. The AUROC of cirrhosis for patients with PSC was 0.95. However, other noninvasive indices (aspartate aminotransferase to platelet ratio index, aspartate aminotransferase/alanine aminotransferase ratio, fibrosis-4 index) had corresponding AUROCs less than 0.80. CONCLUSION: Transient elastography exerts better diagnostic accuracy in AILD patients, especially in PBC patients. The appropriate cutoff values for staging advanced fibrosis and cirrhosis ranged from 9.6 to 10.7 and 14.4 to 16.9 KPa for PBC patients. |
format | Online Article Text |
id | pubmed-10600811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-106008112023-10-27 Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis Chen, Hong Shen, Yue Wu, Sheng-Di Zhu, Qin Weng, Cheng-Zhao Zhang, Jun Wang, Mei-Xia Jiang, Wei World J Gastroenterol Systematic Reviews BACKGROUND: Noninvasive methods have been developed to detect fibrosis in many liver diseases due to the limits of liver biopsy. However, previous studies have focused primarily on chronic viral hepatitis and nonalcoholic fatty liver disease. The diagnostic value of transient elastography for autoimmune liver diseases (AILDs) is worth studying. AIM: To compare the diagnostic accuracy of imaging techniques with serum biomarkers of fibrosis in AILD. METHODS: The PubMed, Cochrane Library and EMBASE databases were searched. Studies evaluating the efficacy of noninvasive methods in the diagnosis of AILDs [autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC)] were included. The summary area under the receiver operating characteristic curve (AUROC), diagnostic odds ratio, sensitivity and specificity were used to assess the accuracy of these noninvasive methods for staging fibrosis. RESULTS: A total of 60 articles were included in this study, and the number of patients with AIH, PBC and PSC was 1594, 3126 and 501, respectively. The summary AUROC of transient elastography in the diagnosis of significant fibrosis, advanced fibrosis and cirrhosis in patients with AIH were 0.84, 0.88 and 0.90, respectively, while those in patients with PBC were 0.93, 0.93 and 0.91, respectively. The AUROC of cirrhosis for patients with PSC was 0.95. However, other noninvasive indices (aspartate aminotransferase to platelet ratio index, aspartate aminotransferase/alanine aminotransferase ratio, fibrosis-4 index) had corresponding AUROCs less than 0.80. CONCLUSION: Transient elastography exerts better diagnostic accuracy in AILD patients, especially in PBC patients. The appropriate cutoff values for staging advanced fibrosis and cirrhosis ranged from 9.6 to 10.7 and 14.4 to 16.9 KPa for PBC patients. Baishideng Publishing Group Inc 2023-10-21 2023-10-21 /pmc/articles/PMC10600811/ /pubmed/37900994 http://dx.doi.org/10.3748/wjg.v29.i39.5503 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Systematic Reviews Chen, Hong Shen, Yue Wu, Sheng-Di Zhu, Qin Weng, Cheng-Zhao Zhang, Jun Wang, Mei-Xia Jiang, Wei Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis |
title | Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis |
title_full | Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis |
title_fullStr | Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis |
title_full_unstemmed | Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis |
title_short | Diagnostic role of transient elastography in patients with autoimmune liver diseases: A systematic review and meta-analysis |
title_sort | diagnostic role of transient elastography in patients with autoimmune liver diseases: a systematic review and meta-analysis |
topic | Systematic Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600811/ https://www.ncbi.nlm.nih.gov/pubmed/37900994 http://dx.doi.org/10.3748/wjg.v29.i39.5503 |
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