Cargando…

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A

Mostrar otras versiones (1)

[Image: see text] 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines, including the chemical probe SGC-CK2-1, are potent and selective inhibitors of CSNK2A in cells but have limited utility in animal models due to their poor pharmacokinetic properties. While developing analogues with reduced intr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Xuan, Ong, Han Wee, Dickmander, Rebekah J., Smith, Jeffery L., Brown, Jason W., Tao, William, Chang, Edcon, Moorman, Nathaniel J., Axtman, Alison D., Willson, Timothy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600890/ https://www.ncbi.nlm.nih.gov/pubmed/37901516 http://dx.doi.org/10.1021/acsomega.3c05377

Ejemplares similares

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2A
por: Yang, Xuan, et al.
Publicado: (2023)

Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses
por: Yang, Xuan, et al.
Publicado: (2022)

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2
por: Yang, Xuan, et al.
Publicado: (2022)

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses
por: Drewry, David H., et al.
Publicado: (2022)

Exploration of Pyrazolo[1,5‐a]pyrimidines as Membrane‐Bound Pyrophosphatase Inhibitors
por: Johansson, Niklas G., et al.
Publicado: (2021)

7-Chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidine
por: Bassoude, Ibtissam, et al.
Publicado: (2013)

NMR-Verified Dearomatization of 5,7-Substituted Pyrazolo[1,5-a]pyrimidines
por: Novikova, Daria, et al.
Publicado: (2023)

2-Anilino-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonitrile
por: Mohamed, Shaaban K., et al.
Publicado: (2012)

Synthesis of Some Novel Pyrazolo[1,5-a]pyrimidine Derivatives and Their Application as Disperse Dyes
por: Al-Etaibi, Alya M., et al.
Publicado: (2011)

Pyrazolo[1,5-a]pyrimidines-based fluorophores: a comprehensive theoretical-experimental study
por: Tigreros, Alexis, et al.
Publicado: (2020)

Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine Derivatives
por: Abunada, Nada M., et al.
Publicado: (2008)

Unusual rearrangement of imidazo[1,5-a]imidazoles and imidazo[1,2-b]pyrazoles into imidazo[1,5-a]pyrimidines and pyrazolo[1,5-a]pyrimidines
por: Gambouz, Khadija, et al.
Publicado: (2019)

7-Chloro-5-(chloromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
por: Xu, Jingli, et al.
Publicado: (2012)

Ethyl 7-methyl-2-phenylpyrazolo[1,5-a]pyrimidine-5-carboxylate
por: Bassoude, Ibtissam, et al.
Publicado: (2013)

Synthesis, Characterization, and Cytotoxicity of Some New 5-Aminopyrazole and Pyrazolo[1,5-a]pyrimidine Derivatives
por: Hassan, Ashraf S., et al.
Publicado: (2015)

Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives
por: Fouda, Ahmed M., et al.
Publicado: (2019)

Functional Pyrazolo[1,5-a]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold
por: Arias-Gómez, Andres, et al.
Publicado: (2021)

Palladium-Catalyzed Intramolecular Cross-Dehydrogenative Coupling: Synthesis of Fused Imidazo[1,2-a]pyrimidines and Pyrazolo[1,5-a]pyrimidines
por: Reddy Kotla, Siva K., et al.
Publicado: (2017)

Catalyst-Switchable Regiocontrol in the Direct Arylation of Remote C–H Groups in Pyrazolo[1,5-a]pyrimidines**
por: Bedford, Robin B, et al.
Publicado: (2015)

Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5-a]pyrimidines
por: Naglah, Ahmed M., et al.
Publicado: (2020)

Structure–Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents
por: Oh, Sangmi, et al.
Publicado: (2021)

Synthesis of structural analogues of Reversan by ester aminolysis: an access to pyrazolo[1,5-a]pyrimidines from chalcones
por: Arias-Gómez, Andres, et al.
Publicado: (2023)

Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
por: Nassar, Ibrahim F., et al.
Publicado: (2022)

4-Hydrazino-1-methylpyrazolo[3,4-d]pyrimidine
por: Dolzhenko, Anton V., et al.
Publicado: (2009)

2-Methyl-5-(4-tolyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
por: Frizzo, Clarissa P., et al.
Publicado: (2007)

Highly enantioselective Rh-catalyzed asymmetric reductive dearomatization of multi-nitrogen polycyclic pyrazolo[1,5-a]pyrimidines
por: Xie, Chaochao, et al.
Publicado: (2023)

Efficient microwave-assisted Suzuki–Miyaura cross-coupling reaction of 3-bromo pyrazolo[1,5-a]pyrimidin-5(4H)-one: towards a new access to 3,5-diarylated 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine derivatives
por: Jismy, Badr, et al.
Publicado: (2021)

Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity
por: Mandour, Asmaa A., et al.
Publicado: (2022)

4-Benzylsulfanyl-1H-pyrazolo[3,4-d]pyrimidine
por: El Fal, Mohammed, et al.
Publicado: (2013)

7-(2,4-Dichlorophenyl)-2-methylsulfanylpyrazolo[1,5-a]pyrimidine-3-carbonitrile
por: Wen, Li-rong, et al.
Publicado: (2009)

The crystal structure of 1,5-dibenzyl-1H-pyrazolo[3,4-d]pyrimidine-4(5H)-thione
por: El Fal, Mohammed, et al.
Publicado: (2015)

Synthesis and Electrophilic Substitutions of Novel Pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidines
por: Atta, Kamal F.M.
Publicado: (2011)

Green One Pot Solvent-Free Synthesis of Pyrano[2,3-c]-Pyrazoles and Pyrazolo[1,5-a]Pyrimidines
por: Al-Matar, Hamad M., et al.
Publicado: (2010)

Branched-chain C-cyano pyranonucleosides: Synthesis of 3′-C-cyano & 3′-C-cyano-3′-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents
por: Kiritsis, Christos, et al.
Publicado: (2011)

Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety
por: Abdelriheem, Nadia A., et al.
Publicado: (2017)

Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Synthesis and Biological Evaluation of Pyrazolo[1,5-a]-pyrimidine-containing (99m)Tc Nitrido Radiopharmaceuticals as Imaging Agents for Tumors
por: Ding, Rui, et al.
Publicado: (2010)

Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5-a]pyrimidine CFTR Activator That Ameliorates Dry Eye Disease
por: Kim, Bo Yi, et al.
Publicado: (2022)

Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure–activity profile
por: Cacciari, Barbara, et al.
Publicado: (2006)

Design, Synthesis, and Antitumor Evaluation of Novel Pyrazolo[3,4-d]pyrimidine Derivatives
por: Kandeel, Manal M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_oo1u0jn6gs9vqc2q0sp3km7dq0