Nosocomial outbreak in a respiratory ward caused by the SARS-CoV-2 Omicron BA 5.2.1 subvariant associated with non-severe illness in vaccinated patients

In this short report, we describe an outbreak of COVID-19 caused by Omicron subvariant BA.5.2.1 in highly vaccinated patients in a respiratory ward in a large acute general hospital in North West London, United Kingdom. The attack rate was high (14/33 (42%)) but the clinical impact was relatively no...

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Autores principales: Gopal Rao, Guduru, Jinjika, Shamiso, James, Dianne, Mukombe, Nyarayi, Patel, Bharat, Chietcheu, Amelie, Macmanus, Christine, Adeboyeku, David, Davies, Emma, Brown, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
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Short Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600893/
https://www.ncbi.nlm.nih.gov/pubmed/37750016
http://dx.doi.org/10.1017/S0950268823001590
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author Gopal Rao, Guduru
Jinjika, Shamiso
James, Dianne
Mukombe, Nyarayi
Patel, Bharat
Chietcheu, Amelie
Macmanus, Christine
Adeboyeku, David
Davies, Emma
Brown, Benjamin
author_facet Gopal Rao, Guduru
Jinjika, Shamiso
James, Dianne
Mukombe, Nyarayi
Patel, Bharat
Chietcheu, Amelie
Macmanus, Christine
Adeboyeku, David
Davies, Emma
Brown, Benjamin
author_sort Gopal Rao, Guduru
collection PubMed
description In this short report, we describe an outbreak of COVID-19 caused by Omicron subvariant BA.5.2.1 in highly vaccinated patients in a respiratory ward in a large acute general hospital in North West London, United Kingdom. The attack rate was high (14/33 (42%)) but the clinical impact was relatively non-severe including in patients who were at high risk of severe COVID-19. Twelve of fourteen patients had COVID-19 vaccinations. There was only one death due to COVID-19 pneumonitis. The findings of this outbreak investigation suggest that while the transmissibility of Omicron BA.5.2.1 subvariant is high, infections caused by this strain are non-severe in vaccinated patients, even if they are at high risk of severe COVID-19 infection.
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spelling pubmed-106008932023-10-27 Nosocomial outbreak in a respiratory ward caused by the SARS-CoV-2 Omicron BA 5.2.1 subvariant associated with non-severe illness in vaccinated patients Gopal Rao, Guduru Jinjika, Shamiso James, Dianne Mukombe, Nyarayi Patel, Bharat Chietcheu, Amelie Macmanus, Christine Adeboyeku, David Davies, Emma Brown, Benjamin Epidemiol Infect Short Paper In this short report, we describe an outbreak of COVID-19 caused by Omicron subvariant BA.5.2.1 in highly vaccinated patients in a respiratory ward in a large acute general hospital in North West London, United Kingdom. The attack rate was high (14/33 (42%)) but the clinical impact was relatively non-severe including in patients who were at high risk of severe COVID-19. Twelve of fourteen patients had COVID-19 vaccinations. There was only one death due to COVID-19 pneumonitis. The findings of this outbreak investigation suggest that while the transmissibility of Omicron BA.5.2.1 subvariant is high, infections caused by this strain are non-severe in vaccinated patients, even if they are at high risk of severe COVID-19 infection. Cambridge University Press 2023-09-26 /pmc/articles/PMC10600893/ /pubmed/37750016 http://dx.doi.org/10.1017/S0950268823001590 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Short Paper
Gopal Rao, Guduru
Jinjika, Shamiso
James, Dianne
Mukombe, Nyarayi
Patel, Bharat
Chietcheu, Amelie
Macmanus, Christine
Adeboyeku, David
Davies, Emma
Brown, Benjamin
Nosocomial outbreak in a respiratory ward caused by the SARS-CoV-2 Omicron BA 5.2.1 subvariant associated with non-severe illness in vaccinated patients
title Nosocomial outbreak in a respiratory ward caused by the SARS-CoV-2 Omicron BA 5.2.1 subvariant associated with non-severe illness in vaccinated patients
title_full Nosocomial outbreak in a respiratory ward caused by the SARS-CoV-2 Omicron BA 5.2.1 subvariant associated with non-severe illness in vaccinated patients
title_fullStr Nosocomial outbreak in a respiratory ward caused by the SARS-CoV-2 Omicron BA 5.2.1 subvariant associated with non-severe illness in vaccinated patients
title_full_unstemmed Nosocomial outbreak in a respiratory ward caused by the SARS-CoV-2 Omicron BA 5.2.1 subvariant associated with non-severe illness in vaccinated patients
title_short Nosocomial outbreak in a respiratory ward caused by the SARS-CoV-2 Omicron BA 5.2.1 subvariant associated with non-severe illness in vaccinated patients
title_sort nosocomial outbreak in a respiratory ward caused by the sars-cov-2 omicron ba 5.2.1 subvariant associated with non-severe illness in vaccinated patients
topic Short Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600893/
https://www.ncbi.nlm.nih.gov/pubmed/37750016
http://dx.doi.org/10.1017/S0950268823001590
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