Tumor recurrence after pathological complete response in locally advanced gastric cancer after neoadjuvant therapy: Two case reports

BACKGROUND: The pathological complete response (ypCR) rate following neoadjuvant chemotherapy for advanced gastric cancer remains low and lacks a universally accepted treatment protocol. Immunotherapy has achieved breakthrough progress. CASE SUMMARY: We report two female patients with gastric cancer...

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Autores principales: Xing, Yu, Zhang, Zi-Li, Ding, Zhi-Ying, Song, Wei-Liang, Li, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600994/
https://www.ncbi.nlm.nih.gov/pubmed/37900239
http://dx.doi.org/10.12998/wjcc.v11.i27.6483
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author Xing, Yu
Zhang, Zi-Li
Ding, Zhi-Ying
Song, Wei-Liang
Li, Tong
author_facet Xing, Yu
Zhang, Zi-Li
Ding, Zhi-Ying
Song, Wei-Liang
Li, Tong
author_sort Xing, Yu
collection PubMed
description BACKGROUND: The pathological complete response (ypCR) rate following neoadjuvant chemotherapy for advanced gastric cancer remains low and lacks a universally accepted treatment protocol. Immunotherapy has achieved breakthrough progress. CASE SUMMARY: We report two female patients with gastric cancer defined as clinical stage cT4N1-2M0. Detection of mismatch repair protein showed mismatch repair function defect, and perioperative treatment with programmed death protein 1 inhibitor combined with S-1+oxaliplatin achieved ypCR. Surprisingly, the patients underwent clinical observation after surgery but developed different degrees of metastasis at ~6 mo after surgery. CONCLUSION: PD-1 inhibitor combined with chemotherapy provides a more strategic choice for comprehensive perioperative treatment of gastric cancer.
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spelling pubmed-106009942023-10-27 Tumor recurrence after pathological complete response in locally advanced gastric cancer after neoadjuvant therapy: Two case reports Xing, Yu Zhang, Zi-Li Ding, Zhi-Ying Song, Wei-Liang Li, Tong World J Clin Cases Case Report BACKGROUND: The pathological complete response (ypCR) rate following neoadjuvant chemotherapy for advanced gastric cancer remains low and lacks a universally accepted treatment protocol. Immunotherapy has achieved breakthrough progress. CASE SUMMARY: We report two female patients with gastric cancer defined as clinical stage cT4N1-2M0. Detection of mismatch repair protein showed mismatch repair function defect, and perioperative treatment with programmed death protein 1 inhibitor combined with S-1+oxaliplatin achieved ypCR. Surprisingly, the patients underwent clinical observation after surgery but developed different degrees of metastasis at ~6 mo after surgery. CONCLUSION: PD-1 inhibitor combined with chemotherapy provides a more strategic choice for comprehensive perioperative treatment of gastric cancer. Baishideng Publishing Group Inc 2023-09-26 2023-09-26 /pmc/articles/PMC10600994/ /pubmed/37900239 http://dx.doi.org/10.12998/wjcc.v11.i27.6483 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Xing, Yu
Zhang, Zi-Li
Ding, Zhi-Ying
Song, Wei-Liang
Li, Tong
Tumor recurrence after pathological complete response in locally advanced gastric cancer after neoadjuvant therapy: Two case reports
title Tumor recurrence after pathological complete response in locally advanced gastric cancer after neoadjuvant therapy: Two case reports
title_full Tumor recurrence after pathological complete response in locally advanced gastric cancer after neoadjuvant therapy: Two case reports
title_fullStr Tumor recurrence after pathological complete response in locally advanced gastric cancer after neoadjuvant therapy: Two case reports
title_full_unstemmed Tumor recurrence after pathological complete response in locally advanced gastric cancer after neoadjuvant therapy: Two case reports
title_short Tumor recurrence after pathological complete response in locally advanced gastric cancer after neoadjuvant therapy: Two case reports
title_sort tumor recurrence after pathological complete response in locally advanced gastric cancer after neoadjuvant therapy: two case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10600994/
https://www.ncbi.nlm.nih.gov/pubmed/37900239
http://dx.doi.org/10.12998/wjcc.v11.i27.6483
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