Development of (225)Ac Production from Low Isotopic Dilution (229)Th

[Image: see text] The promise of (225)Ac targeted alpha therapies has been on the horizon for the last two decades. TerraPower Isotopes are uniquely suited to produce clinically relevant quantities of (225)Ac through the decay of (229)Th. Herein, a rapid processing scheme to isolate radionuclidic an...

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Autores principales: Camacaro, Jose F., Dunckley, Christopher P., Harman, S. Elizabeth, Fitzgerald, Hilary A., Lakes, Andrew L., Liao, Zuolei, Ludwig, Russell C., McBride, Katie M., Yalcintas Bethune, Ezgi, Younes, Ali, Chatterjee, Sayandev, Lilley, Laura M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601055/
https://www.ncbi.nlm.nih.gov/pubmed/37901510
http://dx.doi.org/10.1021/acsomega.3c01769
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author Camacaro, Jose F.
Dunckley, Christopher P.
Harman, S. Elizabeth
Fitzgerald, Hilary A.
Lakes, Andrew L.
Liao, Zuolei
Ludwig, Russell C.
McBride, Katie M.
Yalcintas Bethune, Ezgi
Younes, Ali
Chatterjee, Sayandev
Lilley, Laura M.
author_facet Camacaro, Jose F.
Dunckley, Christopher P.
Harman, S. Elizabeth
Fitzgerald, Hilary A.
Lakes, Andrew L.
Liao, Zuolei
Ludwig, Russell C.
McBride, Katie M.
Yalcintas Bethune, Ezgi
Younes, Ali
Chatterjee, Sayandev
Lilley, Laura M.
author_sort Camacaro, Jose F.
collection PubMed
description [Image: see text] The promise of (225)Ac targeted alpha therapies has been on the horizon for the last two decades. TerraPower Isotopes are uniquely suited to produce clinically relevant quantities of (225)Ac through the decay of (229)Th. Herein, a rapid processing scheme to isolate radionuclidic and radioisotopically pure (225)Ac in good yield (98%) produced from (229)Th that contains significant quantities of (228)Th activity is described. The characterization of each step of the process is presented along with the detailed characterization of the resulting (225)Ac isotopic starting material that will support the cancer research and development efforts.
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spelling pubmed-106010552023-10-27 Development of (225)Ac Production from Low Isotopic Dilution (229)Th Camacaro, Jose F. Dunckley, Christopher P. Harman, S. Elizabeth Fitzgerald, Hilary A. Lakes, Andrew L. Liao, Zuolei Ludwig, Russell C. McBride, Katie M. Yalcintas Bethune, Ezgi Younes, Ali Chatterjee, Sayandev Lilley, Laura M. ACS Omega [Image: see text] The promise of (225)Ac targeted alpha therapies has been on the horizon for the last two decades. TerraPower Isotopes are uniquely suited to produce clinically relevant quantities of (225)Ac through the decay of (229)Th. Herein, a rapid processing scheme to isolate radionuclidic and radioisotopically pure (225)Ac in good yield (98%) produced from (229)Th that contains significant quantities of (228)Th activity is described. The characterization of each step of the process is presented along with the detailed characterization of the resulting (225)Ac isotopic starting material that will support the cancer research and development efforts. American Chemical Society 2023-09-27 /pmc/articles/PMC10601055/ /pubmed/37901510 http://dx.doi.org/10.1021/acsomega.3c01769 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Camacaro, Jose F.
Dunckley, Christopher P.
Harman, S. Elizabeth
Fitzgerald, Hilary A.
Lakes, Andrew L.
Liao, Zuolei
Ludwig, Russell C.
McBride, Katie M.
Yalcintas Bethune, Ezgi
Younes, Ali
Chatterjee, Sayandev
Lilley, Laura M.
Development of (225)Ac Production from Low Isotopic Dilution (229)Th
title Development of (225)Ac Production from Low Isotopic Dilution (229)Th
title_full Development of (225)Ac Production from Low Isotopic Dilution (229)Th
title_fullStr Development of (225)Ac Production from Low Isotopic Dilution (229)Th
title_full_unstemmed Development of (225)Ac Production from Low Isotopic Dilution (229)Th
title_short Development of (225)Ac Production from Low Isotopic Dilution (229)Th
title_sort development of (225)ac production from low isotopic dilution (229)th
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601055/
https://www.ncbi.nlm.nih.gov/pubmed/37901510
http://dx.doi.org/10.1021/acsomega.3c01769
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