Design and Synthesis of d-Ala-d-Ala Silica Gel for a Binding Mode-Based Physicochemical Screening Method

[Image: see text] Vancomycin is a potent and broad-spectrum antibiotic that binds to the d-Ala-d-Ala moiety of the growing bacterial cell wall and kills bacteria. This fascinating binding model prompted us to design and synthesize d-Ala-d-Ala silica gels for the establishment of a new physicochemica...

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Detalles Bibliográficos
Autores principales: Kimishima, Aoi, Suzuki, Yuki, Kosaka, Shohei, Honsho, Masako, Honma, Sota, Sakai, Kazunari, Tsutsumi, Hayama, Inahashi, Yuki, Watanabe, Yoshihiro, Iwatsuki, Masato, Asami, Yukihiro, Nakashima, Takuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601077/
https://www.ncbi.nlm.nih.gov/pubmed/37901494
http://dx.doi.org/10.1021/acsomega.3c03837

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