A new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy

BACKGROUND: Prostate cancer (PCa) is the most common malignancy diagnosed in men. Immune checkpoint blockade (ICB) alone showed disappointing results in PCa. It is partly due to the formation of immunosuppressive tumor microenvironment (TME) could not be reversed effectively by ICB alone. METHODS: W...

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Detalles Bibliográficos
Autores principales: Chen, Zude, Yang, Xiaoshuang, Chen, Zugen, Li, Minzhao, Wang, Wei, Yang, Riwei, Wang, Zuomin, Ma, Yuxiang, Xu, Yulong, Ao, Shan, Liang, Leqi, Cai, Chao, Wang, Changning, Deng, Tuo, Gu, Di, Zhou, Hongqing, Zeng, Guohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601128/
https://www.ncbi.nlm.nih.gov/pubmed/37880708
http://dx.doi.org/10.1186/s12916-023-03094-0

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