MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-κB pathway

BACKGROUND: Neutrophilic airway inflammation is a challenge in asthma management and is associated with poor patient prognosis. Mucin 1 (MUC1), which contains a cytoplasmic tail (MUC1-CT), has been found to mediate glucocorticoid sensitivity in asthma; however, its role in modulating neutrophilic ai...

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Detalles Bibliográficos
Autores principales: Liu, Lu, Zhou, Ling, Wang, Lingling, Mao, Zhenyu, Zheng, Pengdou, Zhang, Fengqin, Zhang, Huojun, Liu, Huiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601133/
https://www.ncbi.nlm.nih.gov/pubmed/37880668
http://dx.doi.org/10.1186/s12931-023-02550-y

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