Usefulness of FAPα assessment in bronchoalveolar lavage as a marker of fibrogenesis: results of a preclinical study and first report in patients with idiopathic pulmonary fibrosis

BACKGROUND: Fibroblast activation protein-α (FAPα) is a marker of activated fibroblasts that can be selectively targeted by an inhibitor (FAPI) and visualised by PET/CT imaging. We evaluated whether the measurement of FAPα in bronchoalveolar lavage fluids (BALF) and the uptake of FAPI by PET/CT coul...

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Detalles Bibliográficos
Autores principales: Lavis, Philomène, Pingitore, Julien, Doumont, Gilles, Garabet, Ani, Van Simaeys, Gaetan, Lacroix, Simon, Passon, Nicolas, Van Heymbeek, Christophe, De Maeseneire, Coraline, Allard, Justine, Collin, Amandine, Huaux, François, Decaestecker, Christine, Salmon, Isabelle, Goldman, Serge, Cardozo, Alessandra Kupper, Bondue, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601150/
https://www.ncbi.nlm.nih.gov/pubmed/37880678
http://dx.doi.org/10.1186/s12931-023-02556-6

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