Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy

Tendinopathy is a debilitating and crippling syndrome resulting from the degeneration of tendon tissue, leading to loss of mechanical properties and function, and eventual tendon rupture. Unfortunately, there is currently no treatment for tendinopathy that can prevent or delay its progression. Exoso...

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Autores principales: Zhang, Yuxiang, Ju, Wei, Zhang, Hong, Mengyun, Liu, Shen, Weiliang, Chen, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601253/
https://www.ncbi.nlm.nih.gov/pubmed/37880763
http://dx.doi.org/10.1186/s13287-023-03431-3
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author Zhang, Yuxiang
Ju, Wei
Zhang, Hong
Mengyun, Liu
Shen, Weiliang
Chen, Xiao
author_facet Zhang, Yuxiang
Ju, Wei
Zhang, Hong
Mengyun, Liu
Shen, Weiliang
Chen, Xiao
author_sort Zhang, Yuxiang
collection PubMed
description Tendinopathy is a debilitating and crippling syndrome resulting from the degeneration of tendon tissue, leading to loss of mechanical properties and function, and eventual tendon rupture. Unfortunately, there is currently no treatment for tendinopathy that can prevent or delay its progression. Exosomes are small extracellular vesicles that transport bioactive substances produced by cells, such as proteins, lipids, mRNAs, non-coding RNAs, and DNA. They can generate by mesenchymal stem cells (MSCs) throughout the body and play a role in intercellular communication and regulation of homeostasis. Recent research suggests that MSCs-derived exosomes (MSCs-exos) may serve as useful therapeutic candidates for promoting tendon healing. This review focuses on the function and mechanisms of MSCs-exos in tendinopathy treatment and discusses their potential application for treating this condition.
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spelling pubmed-106012532023-10-27 Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy Zhang, Yuxiang Ju, Wei Zhang, Hong Mengyun, Liu Shen, Weiliang Chen, Xiao Stem Cell Res Ther Review Tendinopathy is a debilitating and crippling syndrome resulting from the degeneration of tendon tissue, leading to loss of mechanical properties and function, and eventual tendon rupture. Unfortunately, there is currently no treatment for tendinopathy that can prevent or delay its progression. Exosomes are small extracellular vesicles that transport bioactive substances produced by cells, such as proteins, lipids, mRNAs, non-coding RNAs, and DNA. They can generate by mesenchymal stem cells (MSCs) throughout the body and play a role in intercellular communication and regulation of homeostasis. Recent research suggests that MSCs-derived exosomes (MSCs-exos) may serve as useful therapeutic candidates for promoting tendon healing. This review focuses on the function and mechanisms of MSCs-exos in tendinopathy treatment and discusses their potential application for treating this condition. BioMed Central 2023-10-26 /pmc/articles/PMC10601253/ /pubmed/37880763 http://dx.doi.org/10.1186/s13287-023-03431-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Yuxiang
Ju, Wei
Zhang, Hong
Mengyun, Liu
Shen, Weiliang
Chen, Xiao
Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
title Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
title_full Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
title_fullStr Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
title_full_unstemmed Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
title_short Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
title_sort mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601253/
https://www.ncbi.nlm.nih.gov/pubmed/37880763
http://dx.doi.org/10.1186/s13287-023-03431-3
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