Cargando…

Case report: Successful treatment of malignant pericardial effusion with pericardiocentesis, concurrent anti-inflammatory therapy and cancer therapy

Despite significant advancements in systemic anticancer therapies, cardiac tamponade remains a serious and potentially life-threatening complication in metastatic breast cancer (MBC). However, there is a paucity of comprehensive research investigating alternative management approaches, such as peric...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Nuri, Bang, Hyunjin, Park, Hyukjin, Shim, Hyun-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601458/
https://www.ncbi.nlm.nih.gov/pubmed/37900575
http://dx.doi.org/10.3389/fcvm.2023.1285233
_version_ 1785126201272041472
author Lee, Nuri
Bang, Hyunjin
Park, Hyukjin
Shim, Hyun-Jeong
author_facet Lee, Nuri
Bang, Hyunjin
Park, Hyukjin
Shim, Hyun-Jeong
author_sort Lee, Nuri
collection PubMed
description Despite significant advancements in systemic anticancer therapies, cardiac tamponade remains a serious and potentially life-threatening complication in metastatic breast cancer (MBC). However, there is a paucity of comprehensive research investigating alternative management approaches, such as pericardiocentesis and anti-inflammatory therapy (AIT), to effectively address cardiac tamponade and mitigate the risk of heart failure arising from constrictive physiology (CP) in patients with MBC when traditional systemic anticancer drugs fail to yield favorable outcomes. Herein, we describe two cases of MBC with cardiac tamponade that occurred despite the administration of effective systemic anticancer drugs. In each case, pericardial effusion was detected in a patient who was undergoing palliative anticancer therapy for human epidermal growth factor receptor 2 (HER2)-positive MBC. The patients in these cases were successfully treated with pericardiocentesis and AIT (prednisolone and colchicine) for subsequent CP without substitution with their systemic anticancer drugs. Cardiac tamponade and CP are regarded as signs of advanced cancer and are associated with a worse clinical outcome in general; however, they can still be treated with an effective anticancer drug, pericardiocentesis, and management of CP by cardiooncology specialists.
format Online
Article
Text
id pubmed-10601458
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-106014582023-10-27 Case report: Successful treatment of malignant pericardial effusion with pericardiocentesis, concurrent anti-inflammatory therapy and cancer therapy Lee, Nuri Bang, Hyunjin Park, Hyukjin Shim, Hyun-Jeong Front Cardiovasc Med Cardiovascular Medicine Despite significant advancements in systemic anticancer therapies, cardiac tamponade remains a serious and potentially life-threatening complication in metastatic breast cancer (MBC). However, there is a paucity of comprehensive research investigating alternative management approaches, such as pericardiocentesis and anti-inflammatory therapy (AIT), to effectively address cardiac tamponade and mitigate the risk of heart failure arising from constrictive physiology (CP) in patients with MBC when traditional systemic anticancer drugs fail to yield favorable outcomes. Herein, we describe two cases of MBC with cardiac tamponade that occurred despite the administration of effective systemic anticancer drugs. In each case, pericardial effusion was detected in a patient who was undergoing palliative anticancer therapy for human epidermal growth factor receptor 2 (HER2)-positive MBC. The patients in these cases were successfully treated with pericardiocentesis and AIT (prednisolone and colchicine) for subsequent CP without substitution with their systemic anticancer drugs. Cardiac tamponade and CP are regarded as signs of advanced cancer and are associated with a worse clinical outcome in general; however, they can still be treated with an effective anticancer drug, pericardiocentesis, and management of CP by cardiooncology specialists. Frontiers Media S.A. 2023-10-12 /pmc/articles/PMC10601458/ /pubmed/37900575 http://dx.doi.org/10.3389/fcvm.2023.1285233 Text en © 2023 Lee, Bang, Park and Shim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Lee, Nuri
Bang, Hyunjin
Park, Hyukjin
Shim, Hyun-Jeong
Case report: Successful treatment of malignant pericardial effusion with pericardiocentesis, concurrent anti-inflammatory therapy and cancer therapy
title Case report: Successful treatment of malignant pericardial effusion with pericardiocentesis, concurrent anti-inflammatory therapy and cancer therapy
title_full Case report: Successful treatment of malignant pericardial effusion with pericardiocentesis, concurrent anti-inflammatory therapy and cancer therapy
title_fullStr Case report: Successful treatment of malignant pericardial effusion with pericardiocentesis, concurrent anti-inflammatory therapy and cancer therapy
title_full_unstemmed Case report: Successful treatment of malignant pericardial effusion with pericardiocentesis, concurrent anti-inflammatory therapy and cancer therapy
title_short Case report: Successful treatment of malignant pericardial effusion with pericardiocentesis, concurrent anti-inflammatory therapy and cancer therapy
title_sort case report: successful treatment of malignant pericardial effusion with pericardiocentesis, concurrent anti-inflammatory therapy and cancer therapy
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601458/
https://www.ncbi.nlm.nih.gov/pubmed/37900575
http://dx.doi.org/10.3389/fcvm.2023.1285233
work_keys_str_mv AT leenuri casereportsuccessfultreatmentofmalignantpericardialeffusionwithpericardiocentesisconcurrentantiinflammatorytherapyandcancertherapy
AT banghyunjin casereportsuccessfultreatmentofmalignantpericardialeffusionwithpericardiocentesisconcurrentantiinflammatorytherapyandcancertherapy
AT parkhyukjin casereportsuccessfultreatmentofmalignantpericardialeffusionwithpericardiocentesisconcurrentantiinflammatorytherapyandcancertherapy
AT shimhyunjeong casereportsuccessfultreatmentofmalignantpericardialeffusionwithpericardiocentesisconcurrentantiinflammatorytherapyandcancertherapy