An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile

Plant metabolism is constantly changing and requires input signals for efficient regulation. The mitochondrial calcium uniporter (MCU) couples organellar and cytoplasmic calcium oscillations leading to oxidative metabolism regulation in a vast array of species. In Arabidopsis thaliana, genetic delet...

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Autores principales: Gutiérrez-Mireles, Emilia R., Páez-Franco, José Carlos, Rodríguez-Ruíz, Raúl, Germán-Acacio, Juan Manuel, López-Aquino, M. Casandra, Gutiérrez-Aguilar, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601504/
https://www.ncbi.nlm.nih.gov/pubmed/37879964
http://dx.doi.org/10.1080/15592324.2023.2271799
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author Gutiérrez-Mireles, Emilia R.
Páez-Franco, José Carlos
Rodríguez-Ruíz, Raúl
Germán-Acacio, Juan Manuel
López-Aquino, M. Casandra
Gutiérrez-Aguilar, Manuel
author_facet Gutiérrez-Mireles, Emilia R.
Páez-Franco, José Carlos
Rodríguez-Ruíz, Raúl
Germán-Acacio, Juan Manuel
López-Aquino, M. Casandra
Gutiérrez-Aguilar, Manuel
author_sort Gutiérrez-Mireles, Emilia R.
collection PubMed
description Plant metabolism is constantly changing and requires input signals for efficient regulation. The mitochondrial calcium uniporter (MCU) couples organellar and cytoplasmic calcium oscillations leading to oxidative metabolism regulation in a vast array of species. In Arabidopsis thaliana, genetic deletion of AtMICU leads to altered mitochondrial calcium handling and ultrastructure. Here we aimed to further assess the consequences upon genetic deletion of AtMICU. Our results confirm that AtMICU safeguards intracellular calcium transport associated with carbohydrate, amino acid, and phytol metabolism modifications. The implications of such alterations are discussed.
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spelling pubmed-106015042023-10-27 An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile Gutiérrez-Mireles, Emilia R. Páez-Franco, José Carlos Rodríguez-Ruíz, Raúl Germán-Acacio, Juan Manuel López-Aquino, M. Casandra Gutiérrez-Aguilar, Manuel Plant Signal Behav Research Paper Plant metabolism is constantly changing and requires input signals for efficient regulation. The mitochondrial calcium uniporter (MCU) couples organellar and cytoplasmic calcium oscillations leading to oxidative metabolism regulation in a vast array of species. In Arabidopsis thaliana, genetic deletion of AtMICU leads to altered mitochondrial calcium handling and ultrastructure. Here we aimed to further assess the consequences upon genetic deletion of AtMICU. Our results confirm that AtMICU safeguards intracellular calcium transport associated with carbohydrate, amino acid, and phytol metabolism modifications. The implications of such alterations are discussed. Taylor & Francis 2023-10-25 /pmc/articles/PMC10601504/ /pubmed/37879964 http://dx.doi.org/10.1080/15592324.2023.2271799 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Research Paper
Gutiérrez-Mireles, Emilia R.
Páez-Franco, José Carlos
Rodríguez-Ruíz, Raúl
Germán-Acacio, Juan Manuel
López-Aquino, M. Casandra
Gutiérrez-Aguilar, Manuel
An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile
title An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile
title_full An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile
title_fullStr An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile
title_full_unstemmed An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile
title_short An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile
title_sort arabidopsis mutant line lacking the mitochondrial calcium transport regulator micu shows an altered metabolite profile
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601504/
https://www.ncbi.nlm.nih.gov/pubmed/37879964
http://dx.doi.org/10.1080/15592324.2023.2271799
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