Cargando…

Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance

Targeted monoclonal antibody therapy has emerged as a powerful therapeutic strategy for cancer. However, only a minority of patients have durable responses and the development of resistance remains a major clinical obstacle. Antibody-dependent cell-mediated cytotoxicity (ADCC) represents a crucial t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zahavi, David J., Erbe, Rossin, Zhang, Yong-Wei, Guo, Theresa, Malchiodi, Zoe X., Maynard, Rachael, Lekan, Alexander, Gallagher, Rosa, Wulfkuhle, Julia, Petricoin, Emanuel, Jablonski, Sandra A., Fertig, Elana J., Weiner, Louis M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601508/ https://www.ncbi.nlm.nih.gov/pubmed/37878417 http://dx.doi.org/10.1080/15384047.2023.2269637

Ejemplares similares

Transcriptomic forecasting with neural ordinary differential equations
por: Erbe, Rossin, et al.
Publicado: (2023)

Understanding and Targeting Natural Killer Cell-Cancer-Associated Fibroblast Interactions in Pancreatic Ductal Adenocarcinoma
por: Malchiodi, Zoe X., et al.
Publicado: (2021)

Matrix factorization and transfer learning uncover regulatory biology across multiple single-cell ATAC-seq data sets
por: Erbe, Rossin, et al.
Publicado: (2020)

IGF1R and Src inhibition induce synergistic cytotoxicity in HNSCC through inhibition of FAK
por: Lehman, Christine E., et al.
Publicado: (2021)

Enhancing antibody-dependent cell-mediated cytotoxicity: a strategy for improving antibody-based immunotherapy
por: Zahavi, David, et al.
Publicado: (2018)

Monoclonal Antibodies in Cancer Therapy
por: Zahavi, David, et al.
Publicado: (2020)

Targeting Multiple Receptors to Increase Checkpoint Blockade Efficacy
por: Zahavi, David J., et al.
Publicado: (2019)

A Mentee’s Baby Registry: Supporting New Academic Parents in 2020
por: Fertig, Elana J.
Publicado: (2020)

Features of MRI stromal enhancement with neoadjuvant chemotherapy: a subgroup analysis of the ACRIN 6657/I-SPY TRIAL
por: Olshen, Adam, et al.
Publicado: (2017)

Quantifying the Dynamics of Coupled Networks of Switches and Oscillators
por: Francis, Matthew R., et al.
Publicado: (2012)

Learning Dysregulated Pathways in Cancers from Differential Variability Analysis
por: Afsari, Bahman, et al.
Publicado: (2014)

Generating colorblind-friendly scatter plots for single-cell data
por: Guha, Tejas, et al.
Publicado: (2022)

DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma
por: Fitzgerald, Allison A, et al.
Publicado: (2021)

Interrogation of T Cell–enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism
por: Harbison, R. Alex, et al.
Publicado: (2022)

Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors
por: Davis-Marcisak, Emily F., et al.
Publicado: (2021)

CoGAPS 3: Bayesian non-negative matrix factorization for single-cell analysis with asynchronous updates and sparse data structures
por: Sherman, Thomas D., et al.
Publicado: (2020)

Characterization of the effects of defined, multidimensional culture conditions on conditionally reprogrammed primary human prostate cells
por: Tricoli, Lucas, et al.
Publicado: (2017)

Mechanism of action biomarkers predicting response to AKT inhibition in the I-SPY 2 breast cancer trial
por: Wolf, Denise M., et al.
Publicado: (2020)

Kinome Profiling of NF1-Related MPNSTs in Response to Kinase Inhibition and Doxorubicin Reveals Therapeutic Vulnerabilities
por: Grit, Jamie L., et al.
Publicado: (2020)

CancerInSilico: An R/Bioconductor package for combining mathematical and statistical modeling to simulate time course bulk and single cell gene expression data in cancer
por: Sherman, Thomas D., et al.
Publicado: (2019)

shinyMethyl: interactive quality control of Illumina 450k DNA methylation arrays in R
por: Fortin, Jean-Philippe, et al.
Publicado: (2014)

An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models
por: Xia, Wenle, et al.
Publicado: (2013)

Analysis of gene expression of secreted factors associated with breast cancer metastases in breast cancer subtypes
por: Fertig, Elana J., et al.
Publicado: (2015)

Functional Mapping of AKT Signaling and Biomarkers of Response from the FAIRLANE Trial of Neoadjuvant Ipatasertib plus Paclitaxel for Triple-Negative Breast Cancer
por: Shi, Zhen, et al.
Publicado: (2022)

Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response
por: Roller, Devin G., et al.
Publicado: (2021)

Hybrid Modeling of Cell Signaling and Transcriptional Reprogramming and Its Application in C. elegans Development
por: Fertig, Elana J., et al.
Publicado: (2011)

Multifactorial Analysis of Conditional Reprogramming of Human Keratinocytes
por: Ligaba, Segni B., et al.
Publicado: (2015)

Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls
por: Ayyadevara, Srinivas, et al.
Publicado: (2016)

Spatial correlation statistics enable transcriptome-wide characterization of RNA structure binding
por: Busa, Veronica F., et al.
Publicado: (2021)

Proteomics Discovery of Disease Biomarkers
por: Ahram, Mamoun, et al.
Publicado: (2008)

BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib
por: Godinho, M F E, et al.
Publicado: (2012)

Synthesizer: Expediting synthesis studies from context-free data with information retrieval techniques
por: Gandy, Lisa M., et al.
Publicado: (2017)

Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis
por: Lee, Esak, et al.
Publicado: (2014)

A Software Application for Mining and Presenting Relevant Cancer Clinical Trials per Cancer Mutation
por: Gandy, Lisa M, et al.
Publicado: (2017)

Boosting Single-Cell RNA Sequencing Analysis with Simple Neural Attention
por: Davalos, Oscar A., et al.
Publicado: (2023)

Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways
por: Ho, Won Jin, et al.
Publicado: (2021)

Beyond the genome to tissue proteomics
por: Liotta, Lance A, et al.
Publicado: (2000)

A New Scientific Journal Linked to a Genetic Database: Towards a Novel Publication Modality
por: Patrinos, George P., et al.
Publicado: (2008)

DNA methylation regulates TMEM16A/ANO1 expression through multiple CpG islands in head and neck squamous cell carcinoma
por: Finegersh, Andrey, et al.
Publicado: (2017)

Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics
por: Cherry, Christopher, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9j1mhu2fbt3pp5j5cvrifl1lmo