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author Tong, Yi-Gang
Shi, Wei-Feng
Liu, Di
Qian, Jun
Liang, Long
Bo, Xiao-Chen
Liu, Jun
Ren, Hong-Guang
Fan, Hang
Ni, Ming
Sun, Yang
Jin, Yuan
Teng, Yue
Li, Zhen
Kargbo, David
Dafae, Foday
Kanu, Alex
Chen, Cheng-Chao
Lan, Zhi-Heng
Jiang, Hui
Luo, Yang
Lu, Hui-Jun
Zhang, Xiao-Guang
Yang, Fan
Hu, Yi
Cao, Yu-Xi
Deng, Yong-Qiang
Su, Hao-Xiang
Sun, Yu
Liu, Wen-Sen
Wang, Zhuang
Wang, Cheng-Yu
Bu, Zhao-Yang
Guo, Zhen-Dong
Zhang, Liu-Bo
Nie, Wei-Min
Bai, Chang-Qing
Sun, Chun-Hua
An, Xiao-Ping
Xu, Pei-Song
Zhang, Xiang-Li-Lan
Huang, Yong
Mi, Zhi-Qiang
Yu, Dong
Yao, Hong-Wu
Feng, Yong
Xia, Zhi-Ping
Zheng, Xue-Xing
Yang, Song-Tao
Lu, Bing
Jiang, Jia-Fu
Kargbo, Brima
He, Fu-Chu
Gao, George F.
Cao, Wu-Chun
author_facet Tong, Yi-Gang
Shi, Wei-Feng
Liu, Di
Qian, Jun
Liang, Long
Bo, Xiao-Chen
Liu, Jun
Ren, Hong-Guang
Fan, Hang
Ni, Ming
Sun, Yang
Jin, Yuan
Teng, Yue
Li, Zhen
Kargbo, David
Dafae, Foday
Kanu, Alex
Chen, Cheng-Chao
Lan, Zhi-Heng
Jiang, Hui
Luo, Yang
Lu, Hui-Jun
Zhang, Xiao-Guang
Yang, Fan
Hu, Yi
Cao, Yu-Xi
Deng, Yong-Qiang
Su, Hao-Xiang
Sun, Yu
Liu, Wen-Sen
Wang, Zhuang
Wang, Cheng-Yu
Bu, Zhao-Yang
Guo, Zhen-Dong
Zhang, Liu-Bo
Nie, Wei-Min
Bai, Chang-Qing
Sun, Chun-Hua
An, Xiao-Ping
Xu, Pei-Song
Zhang, Xiang-Li-Lan
Huang, Yong
Mi, Zhi-Qiang
Yu, Dong
Yao, Hong-Wu
Feng, Yong
Xia, Zhi-Ping
Zheng, Xue-Xing
Yang, Song-Tao
Lu, Bing
Jiang, Jia-Fu
Kargbo, Brima
He, Fu-Chu
Gao, George F.
Cao, Wu-Chun
author_sort Tong, Yi-Gang
collection PubMed
description A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people in West Africa, resulting in more than 10,000 deaths(1,2). Preliminary analyses of genome sequences of 81 EBOV collected from March to June 2014 from Guinea and Sierra Leone suggest that the 2014 EBOV originated from an independent transmission event from its natural reservoir(3) followed by sustained human-to-human infections(4). It has been reported that the EBOV genome variation might have an effect on the efficacy of sequence-based virus detection and candidate therapeutics(5,6). However, only limited viral information has been available since July 2014, when the outbreak entered a rapid growth phase(7). Here we describe 175 full-length EBOV genome sequences from five severely stricken districts in Sierra Leone from 28 September to 11 November 2014. We found that the 2014 EBOV has become more phylogenetically and genetically diverse from July to November 2014, characterized by the emergence of multiple novel lineages. The substitution rate for the 2014 EBOV was estimated to be 1.23 × 10(−3) substitutions per site per year (95% highest posterior density interval, 1.04 × 10(−3) to 1.41 × 10(−3) substitutions per site per year), approximating to that observed between previous EBOV outbreaks. The sharp increase in genetic diversity of the 2014 EBOV warrants extensive EBOV surveillance in Sierra Leone, Guinea and Liberia to better understand the viral evolution and transmission dynamics of the ongoing outbreak. These data will facilitate the international efforts to develop vaccines and therapeutics. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nature14490) contains supplementary material, which is available to authorized users.
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spelling pubmed-106016082023-10-27 Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone Tong, Yi-Gang Shi, Wei-Feng Liu, Di Qian, Jun Liang, Long Bo, Xiao-Chen Liu, Jun Ren, Hong-Guang Fan, Hang Ni, Ming Sun, Yang Jin, Yuan Teng, Yue Li, Zhen Kargbo, David Dafae, Foday Kanu, Alex Chen, Cheng-Chao Lan, Zhi-Heng Jiang, Hui Luo, Yang Lu, Hui-Jun Zhang, Xiao-Guang Yang, Fan Hu, Yi Cao, Yu-Xi Deng, Yong-Qiang Su, Hao-Xiang Sun, Yu Liu, Wen-Sen Wang, Zhuang Wang, Cheng-Yu Bu, Zhao-Yang Guo, Zhen-Dong Zhang, Liu-Bo Nie, Wei-Min Bai, Chang-Qing Sun, Chun-Hua An, Xiao-Ping Xu, Pei-Song Zhang, Xiang-Li-Lan Huang, Yong Mi, Zhi-Qiang Yu, Dong Yao, Hong-Wu Feng, Yong Xia, Zhi-Ping Zheng, Xue-Xing Yang, Song-Tao Lu, Bing Jiang, Jia-Fu Kargbo, Brima He, Fu-Chu Gao, George F. Cao, Wu-Chun Nature Article A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people in West Africa, resulting in more than 10,000 deaths(1,2). Preliminary analyses of genome sequences of 81 EBOV collected from March to June 2014 from Guinea and Sierra Leone suggest that the 2014 EBOV originated from an independent transmission event from its natural reservoir(3) followed by sustained human-to-human infections(4). It has been reported that the EBOV genome variation might have an effect on the efficacy of sequence-based virus detection and candidate therapeutics(5,6). However, only limited viral information has been available since July 2014, when the outbreak entered a rapid growth phase(7). Here we describe 175 full-length EBOV genome sequences from five severely stricken districts in Sierra Leone from 28 September to 11 November 2014. We found that the 2014 EBOV has become more phylogenetically and genetically diverse from July to November 2014, characterized by the emergence of multiple novel lineages. The substitution rate for the 2014 EBOV was estimated to be 1.23 × 10(−3) substitutions per site per year (95% highest posterior density interval, 1.04 × 10(−3) to 1.41 × 10(−3) substitutions per site per year), approximating to that observed between previous EBOV outbreaks. The sharp increase in genetic diversity of the 2014 EBOV warrants extensive EBOV surveillance in Sierra Leone, Guinea and Liberia to better understand the viral evolution and transmission dynamics of the ongoing outbreak. These data will facilitate the international efforts to develop vaccines and therapeutics. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nature14490) contains supplementary material, which is available to authorized users. Nature Publishing Group UK 2015-05-13 2015 /pmc/articles/PMC10601608/ /pubmed/25970247 http://dx.doi.org/10.1038/nature14490 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by-nc-sa/3.0/This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ (https://creativecommons.org/licenses/by-nc-sa/3.0/) .
spellingShingle Article
Tong, Yi-Gang
Shi, Wei-Feng
Liu, Di
Qian, Jun
Liang, Long
Bo, Xiao-Chen
Liu, Jun
Ren, Hong-Guang
Fan, Hang
Ni, Ming
Sun, Yang
Jin, Yuan
Teng, Yue
Li, Zhen
Kargbo, David
Dafae, Foday
Kanu, Alex
Chen, Cheng-Chao
Lan, Zhi-Heng
Jiang, Hui
Luo, Yang
Lu, Hui-Jun
Zhang, Xiao-Guang
Yang, Fan
Hu, Yi
Cao, Yu-Xi
Deng, Yong-Qiang
Su, Hao-Xiang
Sun, Yu
Liu, Wen-Sen
Wang, Zhuang
Wang, Cheng-Yu
Bu, Zhao-Yang
Guo, Zhen-Dong
Zhang, Liu-Bo
Nie, Wei-Min
Bai, Chang-Qing
Sun, Chun-Hua
An, Xiao-Ping
Xu, Pei-Song
Zhang, Xiang-Li-Lan
Huang, Yong
Mi, Zhi-Qiang
Yu, Dong
Yao, Hong-Wu
Feng, Yong
Xia, Zhi-Ping
Zheng, Xue-Xing
Yang, Song-Tao
Lu, Bing
Jiang, Jia-Fu
Kargbo, Brima
He, Fu-Chu
Gao, George F.
Cao, Wu-Chun
Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
title Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
title_full Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
title_fullStr Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
title_full_unstemmed Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
title_short Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone
title_sort genetic diversity and evolutionary dynamics of ebola virus in sierra leone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601608/
https://www.ncbi.nlm.nih.gov/pubmed/25970247
http://dx.doi.org/10.1038/nature14490
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