Expanding our grasp of two-component signaling in Clostridioides difficile

The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023, https://doi.org/10.1128/jb.00164-23) ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Berumen Alvarez, Orlando, Purcell, Erin B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601699/
https://www.ncbi.nlm.nih.gov/pubmed/37728603
http://dx.doi.org/10.1128/jb.00188-23
_version_ 1785126247425114112
author Berumen Alvarez, Orlando
Purcell, Erin B.
author_facet Berumen Alvarez, Orlando
Purcell, Erin B.
author_sort Berumen Alvarez, Orlando
collection PubMed
description The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023, https://doi.org/10.1128/jb.00164-23) have identified both for the novel C. difficile TCD DraRS. DraRS responds to antibiotics that target lipid-II molecules in the bacterial cell envelope, and regulates the production of a novel glycolipid necessary for bacitracin and daptomycin resistance in C. difficile.
format Online
Article
Text
id pubmed-10601699
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-106016992023-10-27 Expanding our grasp of two-component signaling in Clostridioides difficile Berumen Alvarez, Orlando Purcell, Erin B. J Bacteriol Commentary The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023, https://doi.org/10.1128/jb.00164-23) have identified both for the novel C. difficile TCD DraRS. DraRS responds to antibiotics that target lipid-II molecules in the bacterial cell envelope, and regulates the production of a novel glycolipid necessary for bacitracin and daptomycin resistance in C. difficile. American Society for Microbiology 2023-09-20 /pmc/articles/PMC10601699/ /pubmed/37728603 http://dx.doi.org/10.1128/jb.00188-23 Text en Copyright © 2023 Berumen Alvarez and Purcell. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Berumen Alvarez, Orlando
Purcell, Erin B.
Expanding our grasp of two-component signaling in Clostridioides difficile
title Expanding our grasp of two-component signaling in Clostridioides difficile
title_full Expanding our grasp of two-component signaling in Clostridioides difficile
title_fullStr Expanding our grasp of two-component signaling in Clostridioides difficile
title_full_unstemmed Expanding our grasp of two-component signaling in Clostridioides difficile
title_short Expanding our grasp of two-component signaling in Clostridioides difficile
title_sort expanding our grasp of two-component signaling in clostridioides difficile
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601699/
https://www.ncbi.nlm.nih.gov/pubmed/37728603
http://dx.doi.org/10.1128/jb.00188-23
work_keys_str_mv AT berumenalvarezorlando expandingourgraspoftwocomponentsignalinginclostridioidesdifficile
AT purcellerinb expandingourgraspoftwocomponentsignalinginclostridioidesdifficile

Ejemplares similares