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Exocrine Pancreatic Insufficiency Possibly Related to Atypical Chronic Graft-versus-Host Disease

We report the case of a 66-year-old woman who presented with diarrhea and weight loss approximately 14 months after unrelated allogeneic bone marrow transplantation for acute myeloid leukemia. Her early post-transplant course was notable for mild acute skin graft-versus-host disease (GVHD) and biops...

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Detalles Bibliográficos
Autores principales: Hosokawa, Yuka, Toubai, Tomomi, Ohya, Koichi, Nagano, Yusuke, Ishizawa, Yuki, Hosokawa, Masashi, Sato, Ryo, Watanabe, Shotaro, Yamada, Akane, Suzuki, Takuma, Aizawa, Keiko, Ito, Satoshi, Onozato, Yusuke, Peltier, Daniel, Ishizawa, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601733/
https://www.ncbi.nlm.nih.gov/pubmed/37900836
http://dx.doi.org/10.1159/000533381
Descripción
Sumario:We report the case of a 66-year-old woman who presented with diarrhea and weight loss approximately 14 months after unrelated allogeneic bone marrow transplantation for acute myeloid leukemia. Her early post-transplant course was notable for mild acute skin graft-versus-host disease (GVHD) and biopsy-proven upper gastrointestinal (GI) acute GVHD, both of which resolved with treatment. She then developed weight loss and diarrhea treated with prednisolone for what was thought to be GI late acute GVHD. However, her diarrhea and weight loss persisted. Colonoscopy showed a grossly intact mucosa, and stool studies only confirmed steatorrhea. However, an atrophic pancreas was found on an abdominal computed tomography (CT) scan. Exocrine pancreatic enzymes, such as lipase and pancreatic amylase, were markedly decreased, yet pancreatic endocrine function remained intact. The patient’s diarrhea and weight loss improved upon treatment with pancrelipase. Therefore, we suggest that her exocrine pancreatic insufficiency was likely partly caused by atypical chronic GVHD.