First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report

Small round cell sarcoma is a group of undifferentiated malignancies arising in the bone and soft tissue, notable for Ewing sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subset of these sarcomas, named CIC-rearranged sarcoma. Within th...

Descripción completa

Detalles Bibliográficos
Autores principales: Babkoff, Aryeh, Berner-Wygoda, Yael, Diment, Judith, Kustanovich, Anatoli, Zick, Aviad, Katz, Daniela, Grinshpun, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601800/
https://www.ncbi.nlm.nih.gov/pubmed/37900856
http://dx.doi.org/10.1159/000533519
Descripción
Sumario:Small round cell sarcoma is a group of undifferentiated malignancies arising in the bone and soft tissue, notable for Ewing sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subset of these sarcomas, named CIC-rearranged sarcoma. Within this group, CIC-FOXO4 translocation is an exceedingly rare fusion that has been reported only 4 times in the literature. Herein, we report in-depth the pathological, clinical, and molecular features of a CIC-FOXO4 translocation-driven tumor in a 46-year-old woman.

Ejemplares similares