First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report

Small round cell sarcoma is a group of undifferentiated malignancies arising in the bone and soft tissue, notable for Ewing sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subset of these sarcomas, named CIC-rearranged sarcoma. Within th...

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Detalles Bibliográficos
Autores principales: Babkoff, Aryeh, Berner-Wygoda, Yael, Diment, Judith, Kustanovich, Anatoli, Zick, Aviad, Katz, Daniela, Grinshpun, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601800/
https://www.ncbi.nlm.nih.gov/pubmed/37900856
http://dx.doi.org/10.1159/000533519
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author Babkoff, Aryeh
Berner-Wygoda, Yael
Diment, Judith
Kustanovich, Anatoli
Zick, Aviad
Katz, Daniela
Grinshpun, Albert
author_facet Babkoff, Aryeh
Berner-Wygoda, Yael
Diment, Judith
Kustanovich, Anatoli
Zick, Aviad
Katz, Daniela
Grinshpun, Albert
author_sort Babkoff, Aryeh
collection PubMed
description Small round cell sarcoma is a group of undifferentiated malignancies arising in the bone and soft tissue, notable for Ewing sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subset of these sarcomas, named CIC-rearranged sarcoma. Within this group, CIC-FOXO4 translocation is an exceedingly rare fusion that has been reported only 4 times in the literature. Herein, we report in-depth the pathological, clinical, and molecular features of a CIC-FOXO4 translocation-driven tumor in a 46-year-old woman.
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spelling pubmed-106018002023-10-27 First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report Babkoff, Aryeh Berner-Wygoda, Yael Diment, Judith Kustanovich, Anatoli Zick, Aviad Katz, Daniela Grinshpun, Albert Case Rep Oncol Case Report Small round cell sarcoma is a group of undifferentiated malignancies arising in the bone and soft tissue, notable for Ewing sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subset of these sarcomas, named CIC-rearranged sarcoma. Within this group, CIC-FOXO4 translocation is an exceedingly rare fusion that has been reported only 4 times in the literature. Herein, we report in-depth the pathological, clinical, and molecular features of a CIC-FOXO4 translocation-driven tumor in a 46-year-old woman. S. Karger AG 2023-09-19 /pmc/articles/PMC10601800/ /pubmed/37900856 http://dx.doi.org/10.1159/000533519 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Babkoff, Aryeh
Berner-Wygoda, Yael
Diment, Judith
Kustanovich, Anatoli
Zick, Aviad
Katz, Daniela
Grinshpun, Albert
First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report
title First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report
title_full First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report
title_fullStr First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report
title_full_unstemmed First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report
title_short First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report
title_sort first female patient with a rare cic-foxo4-translocated sarcoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601800/
https://www.ncbi.nlm.nih.gov/pubmed/37900856
http://dx.doi.org/10.1159/000533519
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