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Feminizing Adrenocortical Tumor with Multiple Recurrences: A Case Report

Feminizing adrenocortical tumors (FATs) are exceptionally rare primary adrenal neoplasms that cause high estrogen and low testosterone levels. They are most common in adult males, typically presenting with gynecomastia, hypogonadism, and weight loss. They are almost always malignant, with a poor pro...

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Detalles Bibliográficos
Autores principales: Rich, Joseph M., Duddalwar, Vinay, Cheng, Phillip M., Aron, Manju, Daneshmand, Siamak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601808/
https://www.ncbi.nlm.nih.gov/pubmed/37900824
http://dx.doi.org/10.1159/000533835
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author Rich, Joseph M.
Duddalwar, Vinay
Cheng, Phillip M.
Aron, Manju
Daneshmand, Siamak
author_facet Rich, Joseph M.
Duddalwar, Vinay
Cheng, Phillip M.
Aron, Manju
Daneshmand, Siamak
author_sort Rich, Joseph M.
collection PubMed
description Feminizing adrenocortical tumors (FATs) are exceptionally rare primary adrenal neoplasms that cause high estrogen and low testosterone levels. They are most common in adult males, typically presenting with gynecomastia, hypogonadism, and weight loss. They are almost always malignant, with a poor prognosis and a high recurrence rate. We report a case of a 35-year-old man with an adrenal FAT with high estrogen (181 pg/mL) and low testosterone (37 ng/dL) who presented with gynecomastia, erectile dysfunction, subclinical Cushing syndrome, and pain localizing to different regions of the torso. There was no evidence of metastatic disease initially as seen by visualization of a well-marginated mass on computed tomography scan. Surgical resection of the FAT was performed, and the mass was confirmed to be a low-grade tumor. Clinical symptoms were resolved after surgery. Despite complete resection with negative margins, the patient subsequently had two separate local metastatic recurrences within a few years, treated with a combination of further surgery and medical intervention. This case highlights the unique features of an exceedingly rare adrenal tumor and stresses the importance of early detection and vigilant surveillance following resection due to high recurrence rates.
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spelling pubmed-106018082023-10-27 Feminizing Adrenocortical Tumor with Multiple Recurrences: A Case Report Rich, Joseph M. Duddalwar, Vinay Cheng, Phillip M. Aron, Manju Daneshmand, Siamak Case Rep Oncol Case Report Feminizing adrenocortical tumors (FATs) are exceptionally rare primary adrenal neoplasms that cause high estrogen and low testosterone levels. They are most common in adult males, typically presenting with gynecomastia, hypogonadism, and weight loss. They are almost always malignant, with a poor prognosis and a high recurrence rate. We report a case of a 35-year-old man with an adrenal FAT with high estrogen (181 pg/mL) and low testosterone (37 ng/dL) who presented with gynecomastia, erectile dysfunction, subclinical Cushing syndrome, and pain localizing to different regions of the torso. There was no evidence of metastatic disease initially as seen by visualization of a well-marginated mass on computed tomography scan. Surgical resection of the FAT was performed, and the mass was confirmed to be a low-grade tumor. Clinical symptoms were resolved after surgery. Despite complete resection with negative margins, the patient subsequently had two separate local metastatic recurrences within a few years, treated with a combination of further surgery and medical intervention. This case highlights the unique features of an exceedingly rare adrenal tumor and stresses the importance of early detection and vigilant surveillance following resection due to high recurrence rates. S. Karger AG 2023-09-26 /pmc/articles/PMC10601808/ /pubmed/37900824 http://dx.doi.org/10.1159/000533835 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Rich, Joseph M.
Duddalwar, Vinay
Cheng, Phillip M.
Aron, Manju
Daneshmand, Siamak
Feminizing Adrenocortical Tumor with Multiple Recurrences: A Case Report
title Feminizing Adrenocortical Tumor with Multiple Recurrences: A Case Report
title_full Feminizing Adrenocortical Tumor with Multiple Recurrences: A Case Report
title_fullStr Feminizing Adrenocortical Tumor with Multiple Recurrences: A Case Report
title_full_unstemmed Feminizing Adrenocortical Tumor with Multiple Recurrences: A Case Report
title_short Feminizing Adrenocortical Tumor with Multiple Recurrences: A Case Report
title_sort feminizing adrenocortical tumor with multiple recurrences: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601808/
https://www.ncbi.nlm.nih.gov/pubmed/37900824
http://dx.doi.org/10.1159/000533835
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