αβ,α′β′-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes

Epoxides are an established class of electrophilic alkylating agents that react with nucleophilic protein residues. We report αβ,α′β′-diepoxyketones (DEKs) as a new type of mechanism-based inhibitors of nucleophilic cysteine enzymes. Studies with the l,d-transpeptidase Ldt(Mt2) from Mycobacterium tu...

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Detalles Bibliográficos
Autores principales: de Munnik, Mariska, Lithgow, Jasper, Brewitz, Lennart, Christensen, Kirsten E., Bates, Robert H., Rodriguez-Miquel, Beatriz, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601815/
https://www.ncbi.nlm.nih.gov/pubmed/37815791
http://dx.doi.org/10.1039/d3cc02932h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601815/
https://www.ncbi.nlm.nih.gov/pubmed/37815791
http://dx.doi.org/10.1039/d3cc02932h

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