Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer

In patients with non-small cell lung cancer (NSCLC) harboring a fusion of the neurotrophic receptor kinase (NTRK) gene 1 or 3, treatment with tropomyosin kinase (TRK) inhibitors have shown promising results, however so far no data on efficacy of these agents in patients with NSCLC and NTRK2 fusion a...

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Detalles Bibliográficos
Autores principales: Frehner, Lorenz, Haefliger, Simon, Cerciello, Ferdinando, Grob, Tobias, Schmid, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601816/
https://www.ncbi.nlm.nih.gov/pubmed/37900816
http://dx.doi.org/10.1159/000533572
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author Frehner, Lorenz
Haefliger, Simon
Cerciello, Ferdinando
Grob, Tobias
Schmid, Sabine
author_facet Frehner, Lorenz
Haefliger, Simon
Cerciello, Ferdinando
Grob, Tobias
Schmid, Sabine
author_sort Frehner, Lorenz
collection PubMed
description In patients with non-small cell lung cancer (NSCLC) harboring a fusion of the neurotrophic receptor kinase (NTRK) gene 1 or 3, treatment with tropomyosin kinase (TRK) inhibitors have shown promising results, however so far no data on efficacy of these agents in patients with NSCLC and NTRK2 fusion are available. We present a case of a female patient with NTRK2-positive NSCLC with a complete ongoing response on therapy with larotrectinib, suggesting efficacy of first-generation TRK inhibitors also in NTRK2-positive NSCLC.
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spelling pubmed-106018162023-10-27 Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer Frehner, Lorenz Haefliger, Simon Cerciello, Ferdinando Grob, Tobias Schmid, Sabine Case Rep Oncol Case Report In patients with non-small cell lung cancer (NSCLC) harboring a fusion of the neurotrophic receptor kinase (NTRK) gene 1 or 3, treatment with tropomyosin kinase (TRK) inhibitors have shown promising results, however so far no data on efficacy of these agents in patients with NSCLC and NTRK2 fusion are available. We present a case of a female patient with NTRK2-positive NSCLC with a complete ongoing response on therapy with larotrectinib, suggesting efficacy of first-generation TRK inhibitors also in NTRK2-positive NSCLC. S. Karger AG 2023-09-12 /pmc/articles/PMC10601816/ /pubmed/37900816 http://dx.doi.org/10.1159/000533572 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Frehner, Lorenz
Haefliger, Simon
Cerciello, Ferdinando
Grob, Tobias
Schmid, Sabine
Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer
title Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer
title_full Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer
title_fullStr Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer
title_full_unstemmed Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer
title_short Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer
title_sort complete response on larotrectinib in ntrk2 fusion-positive non-small cell lung cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601816/
https://www.ncbi.nlm.nih.gov/pubmed/37900816
http://dx.doi.org/10.1159/000533572
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