Cargando…

PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

The immune suppressive microenvironment is a major culprit for difficult-to-treat solid cancers. Particularly, inhibitory tumor-associated macrophages (TAM) define the resistant nature of the tumor milieu. To define tumor-enabling mechanisms of TAMs, we analyzed molecular clinical datasets correlati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kauffman, Kevin, Manfra, Denise, Nowakowska, Dominika, Zafari, Mohammad, Nguyen, Phuong A., Phennicie, Ryan, Vollmann, Elisabeth H., O'Nuallain, Brian, Basinski, Sara, Komoroski, Veronica, Rooney, Kate, Culyba, Elizabeth K., Wahle, Joseph, Ries, Carola, Brehm, Michael, Sazinsky, Steve, Feldman, Igor, Novobrantseva, Tatiana I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601817/ https://www.ncbi.nlm.nih.gov/pubmed/37819238 http://dx.doi.org/10.1158/2767-9764.CRC-22-0513

Ejemplares similares

PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells
por: Viramontes, Karla M., et al.
Publicado: (2022)

Is Europe prepared to go digital? making the case for developing digital capacity: An exploratory analysis of Eurostat survey data
por: van Kessel, Robin, et al.
Publicado: (2022)

PSGL-1 is an evolutionarily conserved antiviral restriction factor
por: Jiang, Chao, et al.
Publicado: (2023)

Peritoneal macrophages express both P-selectin and PSGL-1
por: Tchernychev, Boris, et al.
Publicado: (2003)

Targeting of Liposomes via PSGL1 for Enhanced Tumor Accumulation
por: Carlisle, Robert, et al.
Publicado: (2012)

Relevance of PSGL-1 Expression in B Cell Development and Activation
por: González-Tajuelo, Rafael, et al.
Publicado: (2020)

VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of T(H)17 cells
por: Schneider-Hohendorf, Tilman, et al.
Publicado: (2014)

Glycopeptide Analogues of PSGL-1 Inhibit P-Selectin In Vitro and In Vivo
por: Krishnamurthy, Venkata R, et al.
Publicado: (2015)

The development of salt-sensitive hypertension regulated by PSGL-1 gene in mice
por: Yang, Yuhui, et al.
Publicado: (2018)

Biphasic Force-Regulated Phosphorylation Site Exposure and Unligation of ERM Bound with PSGL-1: A Novel Insight into PSGL-1 Signaling via Steered Molecular Dynamics Simulations
por: Feng, Jingjing, et al.
Publicado: (2020)

Tyrosine Sulfation of the Amino Terminus of PSGL-1 Is Critical for Enterovirus 71 Infection
por: Nishimura, Yorihiro, et al.
Publicado: (2010)

Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity
por: Pepin, Marion, et al.
Publicado: (2016)

Psgl-1 Deficiency is Protective against Stroke in a Murine Model of Lupus
por: Wang, Hui, et al.
Publicado: (2016)

PSGL-1 Immune Checkpoint Inhibition for CD4(+) T Cell Cancer Immunotherapy
por: DeRogatis, Julia M., et al.
Publicado: (2021)

Digital Health Paradox: International Policy Perspectives to Address Increased Health Inequalities for People Living With Disabilities
por: van Kessel, Robin, et al.
Publicado: (2022)

The PSGL-1–L-selectin signaling complex regulates neutrophil adhesion under flow
por: Stadtmann, Anika, et al.
Publicado: (2013)

The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression
por: Kappelmayer, János, et al.
Publicado: (2017)

Identification and optimization of peptide inhibitors to block VISTA/PSGL-1 interaction for cancer immunotherapy
por: Niu, Xiaoshuang, et al.
Publicado: (2023)

Anti-amyloidogenic Activity of IgGs Contained in Normal Plasma
por: O’Nuallain, Brian, et al.
Publicado: (2010)

Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence
por: Sun, Liang, et al.
Publicado: (2019)

RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1
por: Ponnusamy, K, et al.
Publicado: (2015)

PSGL-1 restricts HIV-1 infectivity by blocking virus particle attachment to target cells
por: Fu, Yajing, et al.
Publicado: (2020)

PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea
por: Díaz-García, Elena, et al.
Publicado: (2023)

PSGL-1, a Strategic Biomarker for Pathological Conditions in HIV Infection: A Hypothesis Review
por: Zaongo, Silvere D., et al.
Publicado: (2023)

Dimerization of P-Selectin Glycoprotein Ligand-1 (PSGL-1) Required for Optimal Recognition of P-Selectin
por: Snapp, Karen R., et al.
Publicado: (1998)

Tyrosine Sulfation of Native Mouse Psgl-1 Is Required for Optimal Leukocyte Rolling on P-Selectin In Vivo
por: Westmuckett, Andrew D., et al.
Publicado: (2011)

Lipid Raft Is Required for PSGL-1 Ligation Induced HL-60 Cell Adhesion on ICAM-1
por: Xu, Tingshuang, et al.
Publicado: (2013)

PSGL-1 on Leukocytes is a Critical Component of the Host Immune Response against Invasive Pneumococcal Disease
por: Ramos-Sevillano, Elisa, et al.
Publicado: (2016)

PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins
por: Liu, Ying, et al.
Publicado: (2020)

Impact of P-selectin–PSGL-1 Axis on Platelet-Endothelium-Leukocyte Interactions in Fatal COVID-19
por: Granai, Massimo, et al.
Publicado: (2023)

NMR indicates the N-termini of PSGL1 and CCR7 bind competitively to the chemokine CCL21
por: Witt, Robin N., et al.
Publicado: (2023)

IgG Conformer's Binding to Amyloidogenic Aggregates
por: Phay, Monichan, et al.
Publicado: (2015)

Flotillins Interact with PSGL-1 in Neutrophils and, upon Stimulation, Rapidly Organize into Membrane Domains Subsequently Accumulating in the Uropod
por: Rossy, Jérémie, et al.
Publicado: (2009)

PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection
por: Tinoco, Roberto, et al.
Publicado: (2021)

PSGL-1 is a novel tumor microenvironment prognostic biomarker with cervical high-grade squamous lesions and more
por: Lin, Yingying, et al.
Publicado: (2023)

P-Selectin Glycoprotein Ligand 1 (Psgl-1) Is Expressed on Platelets and Can Mediate Platelet–Endothelial Interactions in Vivo
por: Frenette, Paul S., et al.
Publicado: (2000)

Inhibition of P-Selectin and PSGL-1 Using Humanized Monoclonal Antibodies Increases the Sensitivity of Multiple Myeloma Cells to Bortezomib
por: Muz, Barbara, et al.
Publicado: (2015)

The metabonomics study of P-selectin glycoprotein ligand-1 (PSGL-1) deficiency inhibiting the progression of atherosclerosis in LDLR(-/-) mice
por: Li, Binglin, et al.
Publicado: (2018)

Peptide Antagonists for P-selectin Discriminate between Sulfatide-Dependent Platelet Aggregation and PSGL-1-Mediated Cell Adhesion
por: Korporaal, Suzanne J.A., et al.
Publicado: (2019)

The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway
por: Ye, Zhishuai, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_61s2ss13065lsghrjfookr1g9k