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Cognitive Impairment and Risk Factors in Post-COVID-19 Hospitalized Patients
INTRODUCTION: Numerous reports regarding cognitive deficits after the coronavirus disease 2019 (COVID-19), described as “brain fog,” have been published. However, the clinical presentations and risk factors of post-COVID-19 cognitive impairment are controversial. This study aimed to assess (a) the p...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601842/ https://www.ncbi.nlm.nih.gov/pubmed/37900719 http://dx.doi.org/10.1159/000531743 |
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author | Khieukhajee, Jedsada Rojana-udomsart, Arada Srisarakorn, Pinnakarn Wongsurit, Tanaphon Aungsumart, Saharat |
author_facet | Khieukhajee, Jedsada Rojana-udomsart, Arada Srisarakorn, Pinnakarn Wongsurit, Tanaphon Aungsumart, Saharat |
author_sort | Khieukhajee, Jedsada |
collection | PubMed |
description | INTRODUCTION: Numerous reports regarding cognitive deficits after the coronavirus disease 2019 (COVID-19), described as “brain fog,” have been published. However, the clinical presentations and risk factors of post-COVID-19 cognitive impairment are controversial. This study aimed to assess (a) the prevalence of cognitive impairment after COVID-19 hospitalization, (b) characteristics of the cognitive deficits, (c) risk factors of post-COVID-19 cognitive impairment, and (d) comparison of cognitive function between post-COVID-19 patients and healthy people. METHODS: The study comprised 34 SARS-CoV-2-infected patients, admitted to the Neurological Institute of Thailand during the peak of COVID-19 pandemic in 2021–2022. These patients came for neuropsychological and clinical evaluations at 2-week follow-up visit. The cognitive impairment and characteristics were measured by TMSE and MoCA. Clinical risk factors and post-COVID-19 cognitive impairment were assessed. The comparison of cognitive function in post-acute COVID-19 patients and 22 healthy controls was also performed. RESULTS: The prevalence of post-COVID-19 cognitive impairment defined by a total MoCA score below 25 points was 61.76%. Years of education were the only predictive factors related to cognitive impairment. Our multivariate analysis revealed no statistical difference in cognitive outcomes between post-acute COVID-19 patients and healthy controls. CONCLUSION: This study showed a moderate prevalence of cognitive dysfunction after COVID-19 hospitalization similar to previous reports. However, there was no significant difference in cognitive measurements between these patients and healthy people. Whether SARS-CoV-2 infection causes cognitive dysfunction is a myth or fact that still has a long way to prove via further longitudinal study. |
format | Online Article Text |
id | pubmed-10601842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-106018422023-10-27 Cognitive Impairment and Risk Factors in Post-COVID-19 Hospitalized Patients Khieukhajee, Jedsada Rojana-udomsart, Arada Srisarakorn, Pinnakarn Wongsurit, Tanaphon Aungsumart, Saharat Dement Geriatr Cogn Dis Extra Research Article INTRODUCTION: Numerous reports regarding cognitive deficits after the coronavirus disease 2019 (COVID-19), described as “brain fog,” have been published. However, the clinical presentations and risk factors of post-COVID-19 cognitive impairment are controversial. This study aimed to assess (a) the prevalence of cognitive impairment after COVID-19 hospitalization, (b) characteristics of the cognitive deficits, (c) risk factors of post-COVID-19 cognitive impairment, and (d) comparison of cognitive function between post-COVID-19 patients and healthy people. METHODS: The study comprised 34 SARS-CoV-2-infected patients, admitted to the Neurological Institute of Thailand during the peak of COVID-19 pandemic in 2021–2022. These patients came for neuropsychological and clinical evaluations at 2-week follow-up visit. The cognitive impairment and characteristics were measured by TMSE and MoCA. Clinical risk factors and post-COVID-19 cognitive impairment were assessed. The comparison of cognitive function in post-acute COVID-19 patients and 22 healthy controls was also performed. RESULTS: The prevalence of post-COVID-19 cognitive impairment defined by a total MoCA score below 25 points was 61.76%. Years of education were the only predictive factors related to cognitive impairment. Our multivariate analysis revealed no statistical difference in cognitive outcomes between post-acute COVID-19 patients and healthy controls. CONCLUSION: This study showed a moderate prevalence of cognitive dysfunction after COVID-19 hospitalization similar to previous reports. However, there was no significant difference in cognitive measurements between these patients and healthy people. Whether SARS-CoV-2 infection causes cognitive dysfunction is a myth or fact that still has a long way to prove via further longitudinal study. S. Karger AG 2023-08-02 /pmc/articles/PMC10601842/ /pubmed/37900719 http://dx.doi.org/10.1159/000531743 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Research Article Khieukhajee, Jedsada Rojana-udomsart, Arada Srisarakorn, Pinnakarn Wongsurit, Tanaphon Aungsumart, Saharat Cognitive Impairment and Risk Factors in Post-COVID-19 Hospitalized Patients |
title | Cognitive Impairment and Risk Factors in Post-COVID-19 Hospitalized Patients |
title_full | Cognitive Impairment and Risk Factors in Post-COVID-19 Hospitalized Patients |
title_fullStr | Cognitive Impairment and Risk Factors in Post-COVID-19 Hospitalized Patients |
title_full_unstemmed | Cognitive Impairment and Risk Factors in Post-COVID-19 Hospitalized Patients |
title_short | Cognitive Impairment and Risk Factors in Post-COVID-19 Hospitalized Patients |
title_sort | cognitive impairment and risk factors in post-covid-19 hospitalized patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601842/ https://www.ncbi.nlm.nih.gov/pubmed/37900719 http://dx.doi.org/10.1159/000531743 |
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