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Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice

Obesity and exposure to light at night are prevalent in modern society and associated with changes in physiology and behavior that can affect a female's ability to support offspring growth during pregnancy and lactation. A 2X3 factor study of ICR mice was conducted to determine the effect of di...

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Autores principales: Teeple, Kelsey, Rajput, Prabha, Scinto, Sara, Schoonmaker, Jenna, Davis, Corrin, Dinn, Michayla, McIntosh, Mackenzie, Krishnamurthy, Sairam, Plaut, Karen, Casey, Theresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602010/
https://www.ncbi.nlm.nih.gov/pubmed/37843404
http://dx.doi.org/10.1242/bio.060088
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author Teeple, Kelsey
Rajput, Prabha
Scinto, Sara
Schoonmaker, Jenna
Davis, Corrin
Dinn, Michayla
McIntosh, Mackenzie
Krishnamurthy, Sairam
Plaut, Karen
Casey, Theresa
author_facet Teeple, Kelsey
Rajput, Prabha
Scinto, Sara
Schoonmaker, Jenna
Davis, Corrin
Dinn, Michayla
McIntosh, Mackenzie
Krishnamurthy, Sairam
Plaut, Karen
Casey, Theresa
author_sort Teeple, Kelsey
collection PubMed
description Obesity and exposure to light at night are prevalent in modern society and associated with changes in physiology and behavior that can affect a female's ability to support offspring growth during pregnancy and lactation. A 2X3 factor study of ICR mice was conducted to determine the effect of diet [control (CON; 10% fat) or high fat (HF; 60% fat)] and exposure to regular 12 h light:dark cycles (LD) or continuous low (L5) or high (L100) lux of light on gestation length, birth litter size, milk composition and litter growth to lactation day 12. HF diet reduced birth litter size, but increased postnatal d 12 litter weight (P<0.05), whereas constant light tended to increase litter weight (P=0.07). Continuous light increased gestation length, altered dam feed intake, increased serum prolactin and increased final dam and mammary gland weight (P<0.05), while decreasing mammary ATP content and milk lactose (P<0.05). Correlation analysis indicated a positive relationship between final litter weight and mammary size, metabolic stores (e.g. maternal fat pad weight), kcal of feed intake, and gestation length (P<0.05). Although CON mice spent more time eating than HF dams, the calorically dense HF diet was related to greater rates of litter growth to peak lactation. Constant light circadian disrupting effects appear to be confounded by a potential long day photoperiod response exemplified by higher circulating levels of prolactin and increased body and mammary weight of females exposed to these conditions. Other model systems may be better to study the interacting effects of obesity and circadian disruption on reproductive competence.
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spelling pubmed-106020102023-10-27 Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice Teeple, Kelsey Rajput, Prabha Scinto, Sara Schoonmaker, Jenna Davis, Corrin Dinn, Michayla McIntosh, Mackenzie Krishnamurthy, Sairam Plaut, Karen Casey, Theresa Biol Open Research Article Obesity and exposure to light at night are prevalent in modern society and associated with changes in physiology and behavior that can affect a female's ability to support offspring growth during pregnancy and lactation. A 2X3 factor study of ICR mice was conducted to determine the effect of diet [control (CON; 10% fat) or high fat (HF; 60% fat)] and exposure to regular 12 h light:dark cycles (LD) or continuous low (L5) or high (L100) lux of light on gestation length, birth litter size, milk composition and litter growth to lactation day 12. HF diet reduced birth litter size, but increased postnatal d 12 litter weight (P<0.05), whereas constant light tended to increase litter weight (P=0.07). Continuous light increased gestation length, altered dam feed intake, increased serum prolactin and increased final dam and mammary gland weight (P<0.05), while decreasing mammary ATP content and milk lactose (P<0.05). Correlation analysis indicated a positive relationship between final litter weight and mammary size, metabolic stores (e.g. maternal fat pad weight), kcal of feed intake, and gestation length (P<0.05). Although CON mice spent more time eating than HF dams, the calorically dense HF diet was related to greater rates of litter growth to peak lactation. Constant light circadian disrupting effects appear to be confounded by a potential long day photoperiod response exemplified by higher circulating levels of prolactin and increased body and mammary weight of females exposed to these conditions. Other model systems may be better to study the interacting effects of obesity and circadian disruption on reproductive competence. The Company of Biologists Ltd 2023-10-16 /pmc/articles/PMC10602010/ /pubmed/37843404 http://dx.doi.org/10.1242/bio.060088 Text en © 2023. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
Teeple, Kelsey
Rajput, Prabha
Scinto, Sara
Schoonmaker, Jenna
Davis, Corrin
Dinn, Michayla
McIntosh, Mackenzie
Krishnamurthy, Sairam
Plaut, Karen
Casey, Theresa
Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice
title Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice
title_full Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice
title_fullStr Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice
title_full_unstemmed Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice
title_short Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice
title_sort impact of high-fat diet and exposure to constant light on reproductive competence of female icr mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602010/
https://www.ncbi.nlm.nih.gov/pubmed/37843404
http://dx.doi.org/10.1242/bio.060088
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