LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression

Abundant macrophage infiltration and altered tumor metabolism are two key hallmarks of glioblastoma. By screening a cluster of metabolic small-molecule compounds, we show that inhibiting glioblastoma cell glycolysis impairs macrophage migration and lactate dehydrogenase (LDH) inhibitor stiripentol (...

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Detalles Bibliográficos
Autores principales: Khan, Fatima, Lin, Yiyu, Ali, Heba, Pang, Lizhi, Dunterman, Madeline, Hsu, Wen-Hao, Frenis, Katie, Rowe, R. Grant, Wainwright, Derek, McCortney, Kathleen, Billingham, Leah, Miska, Jason, Horbinski, Craig, Lesniak, Maciej, Chen, Peiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602051/
https://www.ncbi.nlm.nih.gov/pubmed/37886538
http://dx.doi.org/10.21203/rs.3.rs-3401154/v1

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