Cargando…

Noise-Induced Hearing Loss Alters Potassium-Chloride CoTransporter KCC2 and GABA Inhibition in the auditory centers

Homeostatic plasticity, the ability of neurons to maintain their averaged activity constant around a set point value, is thought to account for the central hyperactivity after hearing loss. Here, we investigated the putative role of GABAergic neurotransmission in this mechanism after a noise-induced...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parameshwarappa, Vinay, Siponen, Marina, Watabe, Isabelle, Karkaba, Alaa, Galazyuk, Alex, Noreña, Arnaud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602088/ https://www.ncbi.nlm.nih.gov/pubmed/37886592 http://dx.doi.org/10.21203/rs.3.rs-3389804/v1

Ejemplares similares

Reactive Neurogenesis and Down-Regulation of the Potassium-Chloride Cotransporter KCC2 in the Cochlear Nuclei after Cochlear Deafferentation
por: Tighilet, Brahim, et al.
Publicado: (2016)

Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs
por: Reid, Michelle S, et al.
Publicado: (2020)

A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2
por: Friedel, Perrine, et al.
Publicado: (2017)

Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters
por: Chi, Ximin, et al.
Publicado: (2020)

Structural changes in the extracellular loop 2 of the murine KCC2 potassium chloride cotransporter modulate ion transport
por: Hartmann, Anna-Maria, et al.
Publicado: (2021)

Ablation of Potassium-Chloride Cotransporter Type 3 (Kcc3) in Mouse Causes Multiple Cardiovascular Defects and Isosmotic Polyuria
por: Garneau, Alexandre P., et al.
Publicado: (2016)

Structure of the human cation–chloride cotransport KCC1 in an outward-open state
por: Zhao, Yongxiang, et al.
Publicado: (2022)

Molecular architecture of potassium chloride co-transporter KCC2
por: Agez, Morgane, et al.
Publicado: (2017)

Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders
por: Lam, Patricia, et al.
Publicado: (2023)

Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on?
por: Pozzi, Davide, et al.
Publicado: (2020)

Crossing the Chloride Channel: The Current and Potential Therapeutic Value of the Neuronal K(+)-Cl(−) Cotransporter KCC2
por: Tillman, Luke, et al.
Publicado: (2019)

Structures and an activation mechanism of human potassium-chloride cotransporters
por: Xie, Yuan, et al.
Publicado: (2020)

A noninvasive optical approach for assessing chloride extrusion activity of the K–Cl cotransporter KCC2 in neuronal cells
por: Ludwig, Anastasia, et al.
Publicado: (2017)

K(+)/Cl(−) cotransporter 2 (KCC2) and Na(+)/ [Formula: see text] cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation
por: Pethe, Abhishek, et al.
Publicado: (2023)

Expression of the sodium potassium chloride cotransporter (NKCC1) and sodium chloride cotransporter (NCC) and their effects on rat lens transparency
por: Chee, K.N., et al.
Publicado: (2010)

Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA(B) Receptor Protein Complex
por: Wright, Rebecca, et al.
Publicado: (2017)

Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis
por: Adragna, Norma C., et al.
Publicado: (2015)

Current view on the functional regulation of the neuronal K(+)-Cl(−) cotransporter KCC2
por: Medina, Igor, et al.
Publicado: (2014)

The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
por: Zhang, Sensen, et al.
Publicado: (2021)

KCC2 Much Chloride Might Not Be the Only Problem
por: Weston, Matthew
Publicado: (2019)

The roles of sodium-potassium-chloride cotransporter isoform-1 in acute lung injury
por: Hsieh, Po-Chun, et al.
Publicado: (2021)

Phospho‐regulation, nucleotide binding and ion access control in potassium‐chloride cotransporters
por: Chi, Gamma, et al.
Publicado: (2021)

Role of the K(+)-Cl(–) Cotransporter KCC2a Isoform in Mammalian Respiration at Birth
por: Dubois, Christophe J., et al.
Publicado: (2018)

Randomized Trial on the Effect of Oral Potassium Chloride Supplementation on the Thiazide-Sensitive Sodium Chloride Cotransporter in Healthy Adults
por: Wu, Aihua, et al.
Publicado: (2023)

An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switch
por: Sun, Chicheng, et al.
Publicado: (2013)

Developmental hearing loss impairs signal detection in noise: putative central mechanisms
por: Gay, Jennifer D., et al.
Publicado: (2014)

High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter
por: Kortenoeven, Marleen L.A., et al.
Publicado: (2021)

N-terminal Serine Dephosphorylation Is Required for KCC3 Cotransporter Full Activation by Cell Swelling
por: Melo, Zesergio, et al.
Publicado: (2013)

Prenatal Hypoxia Induces Cl(–) Cotransporters KCC2 and NKCC1 Developmental Abnormality and Disturbs the Influence of GABA(A) and Glycine Receptors on Fictive Breathing in a Newborn Rat
por: Caravagna, Céline, et al.
Publicado: (2022)

KCC2 Chloride Transport Contributes to the Termination of Ictal Epileptiform Activity
por: Dzhala, Volodymyr I., et al.
Publicado: (2021)

Both chloride-binding sites are required for KCC2-mediated transport
por: Becker, Lisa, et al.
Publicado: (2023)

Noise-invariant Neurons in the Avian Auditory Cortex: Hearing the Song in Noise
por: Moore, R. Channing, et al.
Publicado: (2013)

The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system
por: Stenesen, Drew, et al.
Publicado: (2019)

The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2
por: Leonzino, Marianna, et al.
Publicado: (2016)

The K–Cl Cotransporter KCC3 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma
por: Shiozaki, Atsushi, et al.
Publicado: (2014)

Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation
por: Little, Robert, et al.
Publicado: (2023)

A Trafficking-Deficient Mutant of KCC3 Reveals Dominant-Negative Effects on K–Cl Cotransport Function
por: Ding, Jinlong, et al.
Publicado: (2013)

Structural Pharmacology of Cation-Chloride Cotransporters
por: Zhao, Yongxiang, et al.
Publicado: (2022)

Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding
por: Doyon, Nicolas, et al.
Publicado: (2016)

Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain
por: Winkelmann, A, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_b2thlq34cjgofmrh1rrrq86oov