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M1 Cholinergic Signaling Modulates Cytokine Levels and Splenocyte Sub-Phenotypes Following Cecal Ligation and Puncture

BACKGROUND: The contribution of the central nervous system to sepsis pathobiology is incompletely understood. In previous studies, administration of endotoxin to mice decreased activity of the vagus anti-inflammatory reflex. Treatment with the centrally-acting M1/M4 muscarinic acetylcholine (ACh) re...

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Detalles Bibliográficos
Autores principales:	Abraham, Mabel N, Nedeljkovic-Kurepa, Ana, Fernandes, Tiago, Yaipen, Omar, Brewer, Mariana R, Taylor, Matthew D, Deutschman, Clifford
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602092/ https://www.ncbi.nlm.nih.gov/pubmed/37886474 http://dx.doi.org/10.21203/rs.3.rs-3353062/v1

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