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GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults

Mitochondrial dysfunction and reactive oxygen species (ROS) accumulation within the substantia nigra pars compacta (SNpc) are central drivers of dopaminergic (DA) neuron death in Parkinson’s disease (PD). Guanylyl cyclases, and their second messengers cyclic (c)GMP, support mitochondrial function, p...

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Detalles Bibliográficos
Autores principales:	Cheslow, Lara, Byrne, Matthew, Kopenhaver, Jessica S., Iacovitti, Lorraine, Smeyne, Richard J., Snook, Adam E., Waldman, Scott A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602097/ https://www.ncbi.nlm.nih.gov/pubmed/37886524 http://dx.doi.org/10.21203/rs.3.rs-3416338/v1

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