Augmenting Mitochondrial Respiration in Immature Smooth Muscle Cells with an ACTA2 Pathogenic Variant Mitigates Moyamoya-like Cerebrovascular Disease

ACTA2 pathogenic variants altering arginine 179 cause childhood-onset strokes due to moyamoya disease (MMD)-like occlusion of the distal internal carotid arteries. A smooth muscle cell (SMC)-specific knock-in mouse model (Acta2(SMC-R179C/+)) inserted the mutation into 67% of aortic SMCs, whereas exp...

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Detalles Bibliográficos
Autores principales: Kaw, Anita, Wu, Ting, Starosolski, Zbigniew, Zhou, Zhen, Pedroza, Albert J., Majumder, Suravi, Duan, Xueyan, Kaw, Kaveeta, Pinelo, Jose E. E., Fischbein, Michael P., Lorenzi, Philip L., Tan, Lin, Martinez, Sara A., Mahmud, Iqbal, Devkota, Laxman, Taegtmeyer, Heinrich, Ghaghada, Ketan B., Marrelli, Sean P., Kwartler, Callie S., Milewicz, Dianna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602100/
https://www.ncbi.nlm.nih.gov/pubmed/37886459
http://dx.doi.org/10.21203/rs.3.rs-3304679/v1

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