Androgen deprivation induces neuroendocrine phenotypes in prostate cancer cells through CREB1/EZH2-mediated downregulation of REST

Although effective initially, prolonged androgen deprivation therapy (ADT) promotes neuroendocrine differentiation (NED) and prostate cancer (PCa) progression. It is incompletely understood how ADT transcriptionally induces NE genes in PCa cells. CREB1 and REST are known to positively and negatively...

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Detalles Bibliográficos
Autores principales: Li, Wenliang, Zheng, Dayong, Zhang, Yan, Yang, Sukjin, Su, Ning, Bakhoum, Michael, Zhang, Guoliang, Naderinezhad, Samira, Mao, Zhengmei, Wang, Zheng, Zhou, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602109/
https://www.ncbi.nlm.nih.gov/pubmed/37886478
http://dx.doi.org/10.21203/rs.3.rs-3270539/v1

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