Retromer stabilization using a pharmacological chaperone protects in an α-synuclein based mouse model of Parkinson’s

BACKGROUND: In the present study we assessed the protective effects of a pharmacological approach to stabilize the retromer complex in a PD mouse model. Missense mutations in the VPS35 gene are a rare cause of familial PD. The VPS35 protein is a subunit of the retromer cargo recognition complex and...

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Detalles Bibliográficos
Autores principales: Eleuteri, Simona, Fang, Tracy Shi Zhang, Cutillo, Gianni, Persico, Michele, Simon, David K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602148/
https://www.ncbi.nlm.nih.gov/pubmed/37886523
http://dx.doi.org/10.21203/rs.3.rs-3417076/v1

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