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Context-specific synthetic T cell promoters from assembled transcriptional elements

Genetic engineering of human lymphocytes for therapeutic applications is constrained by a lack of transgene transcriptional control, resulting in a compromised therapeutic index. Incomplete understanding of transcriptional logic limits the rational design of contextually responsive genetic modules1....

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Detalles Bibliográficos
Autores principales:	Appelbaum, Jacob, Wei, Jia, Mukherjee, Rithun, Ishida, Taylor, Rosser, James, Saxby, Chris, Chase, John, Carlson, Marc, Sather, Cassie, Rahfeldt, Wolfgang, Meechan, Michael, Baldwin, Michael, Flint, Lindsay, Spurrell, Cailyn, Gustafson, Joshua, Johnson, Adam, Jensen, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602160/ https://www.ncbi.nlm.nih.gov/pubmed/37886484 http://dx.doi.org/10.21203/rs.3.rs-3339290/v1

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