Human CD4-Binding Site Antibody Elicited by Polyvalent DNA Prime-Protein Boost Vaccine Neutralizes Cross-Clade Tier-2-HIV Strains

The vaccine elicitation of HIV-neutralizing antibodies with tier-2-neutralization breadth has been a challenge. Here, we report the isolation and characteristics of a CD4-binding site specific monoclonal antibody, HmAb64, from a human volunteer immunized with a polyvalent gp120 DNA prime-protein boo...

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Detalles Bibliográficos
Autores principales: Wang, Shixia, Chan, Kun-Wei, Wei, Danlan, Ma, Xiuwen, Liu, Shuying, Hu, Guangnan, Park, Saeyoung, Pan, Ruimin, Gu, Ying, Nazzari, Alexandra F., Olia, Adam S., Xu, Kai, Lin, Bob C., Louder, Mark K., Doria-Rose, Nicole A., Montefiori, David, Seaman, Michael S., Zhou, Tongqing, Kwong, Peter D., Arthos, James, Kong, Xiang-Peng, Lu, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602183/
https://www.ncbi.nlm.nih.gov/pubmed/37886518
http://dx.doi.org/10.21203/rs.3.rs-3360161/v1

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