Cargando…

Potential mitigating role of ivermectin on the spread of Chlamydia trachomatis by Musca sorbens

Trachoma is the world’s most frequent cause of blindness from an infectious agent. The disease caused by infection is associated with lack of access to sanitation and low hygiene standards. Trachoma is controlled through the Surgery, Antibiotics, Facial cleanliness, and Environmental improvement (SA...

Descripción completa

Detalles Bibliográficos
Autores principales: Selby, Richard, Jeyam, Anita, Tate, Andrew, Kebede, Fikreab, Downs, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602231/
https://www.ncbi.nlm.nih.gov/pubmed/37883529
http://dx.doi.org/10.1371/journal.pntd.0011662
_version_ 1785126353193926656
author Selby, Richard
Jeyam, Anita
Tate, Andrew
Kebede, Fikreab
Downs, Philip
author_facet Selby, Richard
Jeyam, Anita
Tate, Andrew
Kebede, Fikreab
Downs, Philip
author_sort Selby, Richard
collection PubMed
description Trachoma is the world’s most frequent cause of blindness from an infectious agent. The disease caused by infection is associated with lack of access to sanitation and low hygiene standards. Trachoma is controlled through the Surgery, Antibiotics, Facial cleanliness, and Environmental improvement (SAFE) strategy, which delivers azithromycin (AZM) mass drug administration (MDA) in endemic areas. The putative vector Musca sorbens principally reproduce in human faecal matter left in the environment due to open defecation. Ivermectin (IVM) is on the WHO’s essential medicines list and is administered as preventative chemotherapy against two neglected tropical diseases (NTDs)—onchocerciasis, as an annual or bi-annual treatment, and lymphatic filariasis, as an annual treatment in combination with albendazole. Ivermectin has a known inhibitive effect on insects that reproduce in dung. To assess if IVM could be a viable vector control tool against M. sorbens, this study evaluates existing data from trachoma, onchocerciasis and lymphatic filariasis mass drug administration (MDA) operations in Ethiopia. Persistent and recrudescent trachoma in evaluation units (EUs) were examined for whether AZM MDA in EUs was accompanied by IVM MDA, and whether co-administration was associated with greater likelihood of trachoma control. Results show an association suggesting that EUs that received both IVM and AZM MDA benefit from improved control of trachoma in persistent or recrudescent areas, when compared to EUs that received AZM MDA. This initial investigation supports the potential for ivermectin’s use to support SAFE. Findings warrant further work to validate ivermectin’s impact on M. sorbens reproduction through controlled lab and field-based studies.
format Online
Article
Text
id pubmed-10602231
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-106022312023-10-27 Potential mitigating role of ivermectin on the spread of Chlamydia trachomatis by Musca sorbens Selby, Richard Jeyam, Anita Tate, Andrew Kebede, Fikreab Downs, Philip PLoS Negl Trop Dis Research Article Trachoma is the world’s most frequent cause of blindness from an infectious agent. The disease caused by infection is associated with lack of access to sanitation and low hygiene standards. Trachoma is controlled through the Surgery, Antibiotics, Facial cleanliness, and Environmental improvement (SAFE) strategy, which delivers azithromycin (AZM) mass drug administration (MDA) in endemic areas. The putative vector Musca sorbens principally reproduce in human faecal matter left in the environment due to open defecation. Ivermectin (IVM) is on the WHO’s essential medicines list and is administered as preventative chemotherapy against two neglected tropical diseases (NTDs)—onchocerciasis, as an annual or bi-annual treatment, and lymphatic filariasis, as an annual treatment in combination with albendazole. Ivermectin has a known inhibitive effect on insects that reproduce in dung. To assess if IVM could be a viable vector control tool against M. sorbens, this study evaluates existing data from trachoma, onchocerciasis and lymphatic filariasis mass drug administration (MDA) operations in Ethiopia. Persistent and recrudescent trachoma in evaluation units (EUs) were examined for whether AZM MDA in EUs was accompanied by IVM MDA, and whether co-administration was associated with greater likelihood of trachoma control. Results show an association suggesting that EUs that received both IVM and AZM MDA benefit from improved control of trachoma in persistent or recrudescent areas, when compared to EUs that received AZM MDA. This initial investigation supports the potential for ivermectin’s use to support SAFE. Findings warrant further work to validate ivermectin’s impact on M. sorbens reproduction through controlled lab and field-based studies. Public Library of Science 2023-10-26 /pmc/articles/PMC10602231/ /pubmed/37883529 http://dx.doi.org/10.1371/journal.pntd.0011662 Text en © 2023 Selby et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Selby, Richard
Jeyam, Anita
Tate, Andrew
Kebede, Fikreab
Downs, Philip
Potential mitigating role of ivermectin on the spread of Chlamydia trachomatis by Musca sorbens
title Potential mitigating role of ivermectin on the spread of Chlamydia trachomatis by Musca sorbens
title_full Potential mitigating role of ivermectin on the spread of Chlamydia trachomatis by Musca sorbens
title_fullStr Potential mitigating role of ivermectin on the spread of Chlamydia trachomatis by Musca sorbens
title_full_unstemmed Potential mitigating role of ivermectin on the spread of Chlamydia trachomatis by Musca sorbens
title_short Potential mitigating role of ivermectin on the spread of Chlamydia trachomatis by Musca sorbens
title_sort potential mitigating role of ivermectin on the spread of chlamydia trachomatis by musca sorbens
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10602231/
https://www.ncbi.nlm.nih.gov/pubmed/37883529
http://dx.doi.org/10.1371/journal.pntd.0011662
work_keys_str_mv AT selbyrichard potentialmitigatingroleofivermectinonthespreadofchlamydiatrachomatisbymuscasorbens
AT jeyamanita potentialmitigatingroleofivermectinonthespreadofchlamydiatrachomatisbymuscasorbens
AT tateandrew potentialmitigatingroleofivermectinonthespreadofchlamydiatrachomatisbymuscasorbens
AT kebedefikreab potentialmitigatingroleofivermectinonthespreadofchlamydiatrachomatisbymuscasorbens
AT downsphilip potentialmitigatingroleofivermectinonthespreadofchlamydiatrachomatisbymuscasorbens